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Thyroid functions; correlation with retardation of growth in children,
In some children with thyroid lesions, deficiency in serum thyroxine
has been correlated with retardation of growth.
The most striking -nstances
of hypothyroidism were in two boys who showed marked retardation of statural .
growth and bone age.
By 1964, they had developedobvious atrophy of the
thyroid gland with almost complete loss of thyroid function as evidenced
by a failure of the thyroid to take up much if any iodine even after TSH
stimulation..
By this time there were low thyroxine and very high TSH levels
in the blood, . They showed bony dysgenesis, sluggish Archilles tendon
reflexes, puffy faces, and dry skin,
.
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Their response to thyroid hormone
_ Supplement as evidenced by growth spurt, improved appearance, etc. has
been dramatic (See Figs. 11 and12).Several other childrenwho displayed
thyroid nodulariy and whose statural growth was below average showed low
or low-normal serum thyroxine values and poor radioiodine uptake after
TSH stimulation indicating that their thyroids were functionally impaired
a,
my
and operating near their maximum capacity.
Functional deficiency of the |
thyroid was not demonstrated in adults with nodules or carcinoma of the
thyroid.
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|
Influence ofphysiological stress on thyroid abnormalities.
An assessment was made of the relationship of the development of puberty
to the occurrence of thyroid nodules.
Degrees of pubescent changes have
been recorded annually by a grading system,
The two boys that showed
greatest retardation of growth had developed atrophy of the thyroid gland
'
before puberty.
.
Here changes associated with puberty were delayed.
There
may be some association between the apparent increased demand for thyroid
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