- 31 cd
a burden range of 0.5 uCi to 50 uCi the observed tumor incidence
fluctuated between 0.04 and 0.3°7,
All of these lung experiments involved intense exposures
and a significant level of carcinogenesis.
Severe damage
and disruption of tissue were associated with the exposures.
The most relevant lung experiment is Bair's Pu23905
inhalation study with beagles 52-54
Exposure was to
particulates of 0.25 u or 0.5 u median diameter; burdens were
in the uCi range.
Twenty of the 21 dogs that survived more
than 1600 days post 6xposure had lung cancer.
- cancers were multicentric in origin.
Many of these
The cancers again
appeared in conjunction with severe lung injury.
natural incidence of the disease is small,
Since the
it appears that
at this level of exposure the induction of lung cancer is a
me
certainty during the normal beagle iife span.
At the same
_ —_—
51/
Cember, H., Op. cit.
52/
Bair, W.J.,
J.F.
Park,
and W.Jd.
‘study of inhaled plutonium in dogs,' "
(Richland),
AFWL-TR-65-214,
1966
Clarke,
“Long-term
Battelle Memorial Institute
(AD-631
690).
53/ Park, J.F., W.J. Clarke and W.d. Bair, "Chronic effect S
of inhaled 232pu02 in beagles," Battelle-Northwest Laborato oY
Annual Report for 1967 to the USAEC Division of Biolesy an
Medicine, Vol. I, Biological Sciences, BNWL-714, 1968,
~
fl
“yy
pp.
54/
2.3-3.4,
/
Park, J.F., et al,
Transuranium Elerents
ea
.
"Frooress in Beagle Deg Studies with
at Battello-Nortiawast,"
Vol. 22, No. 6, June 1972, pp.
fC03-c10.
Health
Phreicce,