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Others have observed carcinomas and sarcomas in rats
and mice after intense exposure of the skin to ionizing radiation??743,
Cancer induction is generally a frequent event
tal
in these experiments.
Even at elevated doses,
such as
oer
12,000 rad of 1 MeV electrons, Boag and Glucksmann induced
oo.
“5 sarcomas/100 cm2 in rats>’.
A few results
for rabbits,
obtained at Hanfora?®4?,
sheep,
Despite
the
and Swine were
small number of animals
*
37/
Withers, H.R.,
“The dose-survival relationship for
.irradiation off epithelial cells of mouse skin," Brit. J.
Radiol. 40, 1967, pp- 187-194.
38/ Hulse, E.V., “Tumours of the skin of mice and other
Gelayed effects of external beta irradiation of mice using
90sr and 34P," Brit, J, Cancer 16, 1962, pp. 72-86.
39/
.-Boag,
J.W.
and A.
Glucksmann,
“Production of cancers in
rats by the local application of Beta-rays and of chemical
carcinog2ns," Procress in Radiobioloazyv, J.S. Mitchell,
B.E. Holmes, and C.L. Smith, eds. Proceedings of the Fourth
International Conference on Radiobiology held in Cambridge,
14-17 August 1955. Edinburgh, Oliver and Boyd, 1956, pp. 476-479.
40/ George, L.A. and L.K. Bustad, "Gross effects of beta rays
on the skin," Hanford Atomic Products Operation, Bioloszy
Research Annual Report for 1356, HW-47500, 1957, pp. 135-141.
41/
Georce, L.A. II, R.L. Pershing, §. Marks, and L.k.
Bustad, "Cutaneous fihrosarcoma in a rabbit following beta:
irradiation," Hanford Atomic Products Operation, Biology
Research Annual Report for
1959,
HW-65500,
1960,
pp.
68-69.
42/ Ragan, H.A., W.J. Clarke and L.K. Bustac, “Late effects
of skin irradiation," Battelle-Ncrthwest Laboratory Annual
Report for
43/
1965
in the Biological Sciences,
BNWL-280,
Karagianes, W.T., E.gp. Howard and J.l. F
1956,pp.
a
Northwest Lazcratory Annual Report for 1967 to the YENL
of Biolosy and Medicine,
- 1968, op. 1.10-1.11
Vol.
I,
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