A Cell Risk Meters. Microdosimetry
“Microdosimetry”, altnough originally apolied only
techniques devised by Rosst et al.
Dec
cell
and
thelr
caynitude,
Aas
anscrumental and calculativnai
_
re
the
Guanticties.*
[f
is
geriau3
(2-5)
aow
vost
to measure
Deen extended
iwersaches
in
to
the context ot
t be number of
include
Fits
both
1
tlia.inactiaz
to
veserice
tne
instrument
approach.
A mferocosineter
equivalent sas.
is sitcly a nrovortionil cvuunter contaiiing
ALtnough
partial evacuation
toe countec may be centimeters
ind suitable sealing pernits
subcellular volumes af several microns
fapinges om or traverses
the
ready
ia diameter.
Tacr
instrument, a siagle “hit”
the resulting “event", measured in terns of
cascade,
taken as
Thus
instrurent can be
t ragisters
re
that
the
the magnituce of
the size of
the dosimetry of
rt
ia several quite siznaificant
_
The
rapid,
tissue volumes.
the
in the
Hoeever,
sense
ic
tacro-phantons
The recovery
Thus, ome obtains not oaly
tne stochastic: ly delivered hit sizes, but aiss
idea of discrete,
sizz of
time
so thac, with low-to-tocdest exposure
SC
aach hit is registered
separately.
Steetrcun of
tne
respects from the usual
organs or other
the instrument is’extremely
tates,
ts rez
che “hie size"
the “cell dose” delivered.
used
c*
line a particle
regarcet as a “cell omanton”,
diffe $
in
the hic,
ilameter,
situlation of
the size of
is
in
Che
the
tutal
stucnastic hizh-density energy cepusiticas +
from radiation exposure crobably originated early with Dessacer’s “soln:
heat”
tneory and was certainly weil appreciated by Lea (5).
ieeas were not formaliy cevelopec until
by Rossi
(2-4).
the quantity LET,
Its use ras been more
the “aicrodusimeter” «435
these
invented
in the context of a substitute foc
to descrive energy definition within a non-anatomically
defined “gross sensitive volume” within
dose” was probably applied
developed
however,
the cell.
The idea of a “cell
firse by Bond and Fetnendezen (10), and
in NCR? Report No. 63 (11).
The idea of a microdosimeter bein;
conceptually a cell shanton with whicn cell dose could Se determined with
stochastic douse delivery
relatively cecent (Bond et al.,
sefs. 6 and 12}.
co
al.,
is
soos i
Felnendegen et