74 in function, energy requirements and metabolic chemistry. It was required that the tissue have a high specific requirement for zine and a fairly steady rate of metabolism. The tissues examined from the 1958 fish collections were all, in some way, unsatisfactory. Stomach and liver have a high specific requirement for zine which is a component of enzymes involved in the regulation of acid-base equilibrium and in digestive processes in these organs (Vallee, 1957). They are not, how~- ever entirely satisfactory because of the variability of zinc requirements stemming from periodic metabolic activity changes linked to feeding. Gonad tissue is also unsatisfactory due to the periodicity which characterizes its metabolism. Gills, due to the tendency of particulate matter from the water to stick to the gill filaments, are also unsatisfactory. Muscle and bone maintain a fairly steady rate of metabolism, but are not entirely satisfactory due to their low zine levels. on the other hand, Leiner The eyes, sgeem to fulfill the basic requirements. (1943) reported concentrations of zinc in the retina of the eyes of bony fishes at least three times as great as in other tissues. The acid-base equilibrium of the vitreous humor is regulated by the ubiquitous zinc enzyme, (Maetz, carbonic anhydrase 1956), and an essential step in the chemistry of the visual process is catalyzed by the retinal enzyme, retinene

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