10
Table 6,
Mitotically Connected Abnormalitics
(per 1,000 Erythroblasts)
Giant
Aperrant
Subject Binucleated
"Erbl. “<|Karyomere some in Neutrophils
No.
Mitosis
067
oO
T- 3
T— 6
4
4
"ILS
0
i
|
2
K— 2
1.3
|
2
0
2
0
3.3
K— 1
0.67:
13
13
K— +
K— 5
K— 6
0
K— 8
K—-9;
K—10
K—l!
K—12)
K-13 |
K-16
Normal |
1
2
3
4
5
7.3
5.3
0
=
067 0
|
o
0
13
+
_
_
=
4
0
0
2
0
0.
—
_
_
|
'
|
|
0
2
(OO
|
,
,
|
.
_
0
O
0.67
0.67
+
067
2
27
2
4
0
—_
2:
Bor
=
|,
°o
=
13
|)
—
0
0
2
13
+
=
0
0
0
4
130
0
0
|
—
_
dicentric chromosomes and monocentric abnormal
chromosome-type
chromosomes,
abnormalities
which have never been observed in normal
persons, occurred in them. Dicentrics were found
in 7 cases, and monocentric abnormal chromo-
somes were present in all of the cases examined.
Also, ancuploid cells occurred in a high frequency.
In view of the importance of these findings,
long term observations are to be made. The
chromosome abnormalities of these patients were
reported elsewhere together with those of other
radiation-exposed people, i.e. atomic bomb survivors, Thorotrast-injected patients, etc.'”’
G. Other Laboratory Studies
Several laboratory studies were made on the
subjects. The results of these examinations were
mostly within normal range. However, some
of them indicated slight abnormalities.
ZTT: Normal.
Thymol turbidity test:
Cases K-5, 6,8 and 9 revealed high values (7~10).
leteric index:
Cases *K-8, 1], 13 and 16 show-
ed slight increase (nearly 9).
Serum alkaline phosphatase:
Cases K-6, 7, 10 and 11 indicated in-
In the histological sections, all showed nor- |
mal cellular marrow.
c. Haemorrhagic diathesis
As to the haemorrhagic diathesis, no abnormalities were found.
F. Chromosome Studies
Chromosome studies succeeded on 13 of the
exposed persons. The observation of chromosomes was made by cultures of peripheral leuco-
cytes prepared in accordance with the method by
Moorhead, ef al. with a slight modification.
Samples were obtained 72 hoursafter initiation
of culture, and 200 metaphases were examined
in each culture for all the cases except one
case. The control observations were based on 11
normal males, aged 28-53,
creased values (12~18 King-Armstrong
unit).
GOT:
GPT:
data
was obtained
All data were within normal range.
BSP test:
Cases T-6 (12.593), K-6 (5-7.593) and
K-13) (5-7.5%) revealed slight high
retention (45 min.).
Erythrocytes sedimentation rate:
All were normal.
Tests for syphylis: All were negative.
Routine urine analyses:
A sample from Case T-7 was positive
for sugar (1/10~1/49).
normal.
observations are shown in Table 7.
As shown in the table, frequencies of chromo-
pathological
except for T-7 (70 Frankel unit).
Paperelectro|phoresis: No abnormal findings were
obtained.
Total cholesterol: All were normal.
The results of the
some aberrations in the exposed persons were
much higher than those in the normal. Further,
No
Others were
Feces;
No parasites were observed.
PBI:
Five cases were measured for PBI con-
tent by courtesy of Dr. Tachibana (St.