a
Table 14
Serum Iodine
Serum Protein-Bound Iodine
Date
Group
1959
1962
1963
Rongelap
Rongelap
Rongelap
1964
1964
Medical team
Rangelap
1965.
1965
1966
1966
Rongelap exposed
Rongelap unexposed
Rongelap exposed
Uurik exposed
1959
Rongelap
,
Average. ug%
Range. ug%
No. samples
Percent over 8 ug%
6.2
8.6
8.1
4.1- 9.2
4.6~ 12.0
1.9- 12.0
12
14
29
16
64
66
7.6
7.0
6.1
11.8
4.1-11.9
3.9 - 10.7
3.1- 11.8
6.9 - 28.7
31
19
9
25
42
28
16
92
49
71
2.5- 6.9
2.0 - 10.2
10
1!
36
Serum Butanol-Extractable Iodine
4.9
2.7-
8.7
12
Serum Iodine Chromatography
Group
Total iodine, Av ng%
1954-1964
1965-1966
Rongelap
Rongelap
6.98
7.40
1964-1966
Americans
1966
Curik
18.10*
5.09
lodoprotein, Av ug%
=9—-7,4+7;, Av pe%
No. samples
2.22
2.80
4.53
4.21
19
18
0.80
3.76
25
9.20
4.00
5
*One Uurik sample wasquite high in total iodine (32.0 n.e%) suggesting contamination of this sample. The remain-
ing 4 samples showedtotal iodine levels very nearly equal to the combined iodoprotein and thyroxine values.
iodine plustriiodothyronine iodinein these sera
was 4.53 ug%. Five plasma samples from Utirik
people assayed in 1966 showed an unusually high
average of 9.2 ug% of iodoprotein. (See Table 14.)
These data may be compared with results obtained on 25 normal North Americancontrols residing temporarily in Washington, D.C., who
showed an average serum iodoprotein level of 0.8
ug% and an average T,+ 7, iodine level of 3.76
pg.
Dietary lodine and Urinary Excretion of lodine.
The supplyof iodine in the Marshallese diet has
generally been considered adequate in view of the
5008310
cal Laboratory in 1965 gave an average value of|
105 ug iodine per day (range: 19.5 to 279), which
is within the range of values found in an unselected population living in the Eastern United
States.** A complete table of urinary iodine excretion data is presented in Appendix 4.
Thyroid Uptake of Radioiodine.
Uptake of
radioiodine by the thyroid was tested in 1965 on
21 Marshallese (12 exposed and 9 comparison
adults) with no known thyroid abnormalities.
Studies with ‘**I were performed with a collimated |-in. Nal crystal 25 cm from the patient’s
neck. The '**I was milked daily from tellurium132 bound to a resin by elution with 0.1 Af
NH,OH, andit was calibrated against a '**Cs
standard. The '**I (5 to 10 pCi) was administered
by mouth before breakfast, and counts were obtained over the neck at =, 1, 2, 3, and 4 hr; a
single 3-hr urine was assayed for '**I. A predose
count of the neck was performed, since a small
amount of what was presumed to be ‘*'Csin-
_— —
The average value for the amount of thyroxine
large consumption of seafood. Analysis of 24-hr
urine samples from 28 people at the Boston Medi-
en eed
tion in PBI is a general phenomenon whichaffects
the entire population.
The difference between PBI and BEI in 12 cases
was 1.5 pg%, which is somewhat greater than an
average value of 0.6 ug% in the United States.*'-**
This was suggestive evidence for the presence of
iodoprotein in serum, and the results obtained by
column chromatography substantiate this, as an
average iodoprotein level of 2.22 ug% was found.