TT
RI
; Cronxiry et
Cases,
Hematological Effects on Heavily Irradiated Japanese Fistemmen
omparit ng
69
by reactor ac.
al, 1956
100
Fig. 4
witb
h ann
orm
aa2l
80
voters L year
’ 6years
&
Nd cases exposed
cumulative percent
Sa
- contral
Leukocytes of Bikini patients
(J) (cumulative).
345 67 6 9 10tl1215
leukocytes x 108
ao
— T-3
;
:
-
leukocytes
;
-
sos
Le a
e
ahr
“ne.
.
o
. re
:
“ay
e
mh)
HS
mB. :
own
“<2
ee
S at Sth
week
e
:
WiIth
the begi
Plastic an
d th n t
urne
m
Ove
e,t Was
not Compl d
an em
ete
Was not
aplastic
the critica}
Stage
.
i
ie
nuclea
Phils toxic r debris of
g @ulation
s
ce abnorma
litieg o
f
° maarhably
e
.
After
20rmal pe o5ne
rson
a
a=:
2
‘
e
Pa2
re
&
ON an an
.
‘on Curve
s of leuk
o.
©
the Jefe of
the
z=
=
:
2
hey
Xamined
~
lymphocytes
Wse
erryed,
neutrophils
-_
“
HNWEUHYSBOOS
Tv
“e.
rree KG
HMNwWRUDWO OS
.~
HN WED UOWO
s
Fig. 5 Changes in the number of leuko-
cytes, neutrophils and lymphocytes.
+
G7 142) 354249% 69700
ar
6
:
123.456 78 91011 12131415
years
time after exposure
of normal Japanese. In the case of erythrocytes, 2 years after the expusure,
the curve approximately came back’ to normal. A similar tendency is seen
in the cumulative distribution curves of platelets.
However, in a few cases slight neutropenia is still observed. Figure 5 shows
the changesof total leukocytes, neutrophils, and lymphocytes of 2 cases which
are representative for severe injury.
A small increase of ‘‘mitotically connected abnormalities”, i. e. karyomeres
of erythroblasts, were observed in bone marrow smears of a few cases alter
10 years.
Cytogenetical studies have been performed since several years.
The
results are summarized as follows (IsHiHARA and Kumatont 1965; 1967; 1969).
1. The frequency of aneuploid cells was 2~3 per cent, which was not