838 TAMPLIN AND MINKLER 1. They will assure that no important aspect of the overall problem is overlooked. 2. The integration of data generated in diverse research projects may lead to the solution of problems without lengthy experimentation through the development of theoretical models concerning fallout and related problems. The collection and critical evaluation of worldwide input data and the integration of such data into theoretical models will reveal crucial gaps in our knowledge. 3. The experimental programs can thus be directed towardfilling gaps rather than repeating previously recorded efforts. At the same time the existing literature will furnish important guidelines in assur- ing appropriate experimental design. Some of the gaps will become fruitful areas of investigation for our Bio-Medical Research Group, and others may more appropriately be left to other laboratories within the AEC or elsewhere. 4. Our scientists will not pursue programs that are being adequately investigated by others. The overall problem of radionuclides in the biosphere can be broken down into three major categories: (1) the source of the nuclide, (2) the transport of the nuclide from the source, and (3) the interaction of the nuclide with the biosphere. The information-retrieval and -integration system will be directed to problems within each of these categories. Figure 1 is a flow chart of the overall mission problem beginning with the source, proceeding through the transport and interaction phases, and ending with the burden in man. Figure 2 is a further breakdown of the physiology and biochemistry of the interaction phase of the problem. Source The basis for concern over radionuclides in the biosphere is that they are produced in large quantities in nuclear detonations and reactors. It is therefore essential that we obtain, evaluate, and integrate all data pertinent to concentration, chemical state, or physical state of radionuclides that are produced and could be released to the biosphere. In other words, it is desirable to have an inventory of fission products and induced nuclides that could be produced in anyof a variety of situations. Thus all the pertinent literature from past tests must be collected and evaluated along with the literature on laboratory research in this problem area. In addition, a great deal of theoretical study has been applied to this problem area, and the techniques and results of these efforts must be evaluated. Transport Transport implies conduction of radionuclides away from the source by natural phenomena and includes atmospheric (tropospheric and stratospheric) and water—soil transport. Another very

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