anemia from suppression of red cell production and hemorrhage.
descriptions of
Detailed
this syndrome in man and animals are described (1,2,5-13).
This picture of the three radiation syndromes, which overlap to a
certain extent, is based primarily upon animal experimentation.
Human
experienee (1,2,14-20) indicates
that man corresponds reasonably closely to
the general mammalian response.
There are some differences
the time of occurrence of signs and symptoms.
in respect to
The experience of the
Japanese at Hiroshima and Nagasaki exposed to gamma’ radiation from a
high-altitude nuclear device in which the fireball did not touch the ground
are described in detail by Oughtersen and Warren (1).
Hubner and Fry (2)
have gathered together the total human experience in radiation injury and
“tts Management, with the exception of
and
the Japanese atomic bomb casualties
the Marshallese fallout casualties.
_(1,15,24), nor would one have expected it to be observed since doses to
the syndrome were well within
total destruction and no
The GIS, with deaths in the first week, are well documented
clinically and pathologically as are deaths from the HS (1,15,18).
"case of man,
the sequential sequence of deaths and depression of blood
“counts is different from that in animals.
develop ia man.
It takes longer for the HS to
For example, deaths from infection were most prevalent in
Ypanese as late as
mals,
In the
oe
P survival.
the area of
Sa
‘produce
nerrergenpernememes o>
The CNS was not observed by the Japanese at Hiroshima or Nagasaki
eens
Radiation Injury in the Japanese at Hiroshima and Nagasaki:
the seventh week.
This is in contrast to other
where deaths from the acute phase are uncommon later
fy).
than the
The correlation of neutrophil c unts with
tality, is shown in Figure 2.
The data in Figure 2 are based on dogs
rare illustrated in Figures 3 and 4.
eat leukocyte counts in
In addition, it was shown that
the Japanese were observed in
week after exposures to the nuclear radiation (20).
the fifth
to
the
A comparable
ence in the depression of granulocytes was also seen in the Marshallese
4
é
ed to fallout radiation (5).
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omnes oe
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s
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