ee EY aeB cee ale sie eaSE
7.
Granulocyte transfusions would be desiratle to prevent intection
in patients with a sranulocyte count falling below 2OU/ul.
these are not practical on any
5.
large
infection in
dBacterial
or
fever
flora,
Since
therapy even
4
In>
is an
arr
a
ne
og
-
than 24 hours
\ —
.4
The onset ot
have b
ane
techni
‘
ORR
sensitivities
and 3
:
»
wee
therapy should
obtained.
If
cultures
are
negative
or fever
ery thropote
Macrophages
produce
eee
e
persists,
=
antibiotic
therapy,
Pon
upon
After initiation of broad-“spectrum?
it should be continued until
washed packed
red
blood cells should be given as
indicated
functional é
colony-stimy
to kee.
&fanuloc
the hemoglobin above 3.5 g.
10.
All bleod products
infusion into
the patient in order
proliferate and
\1,
should be
linpair
the possibility
be within
of a bone marrow
uncertainty about
inhomogeneity of
the
limits of
Suppressed ana
therapy.
the dose,
rescue of
approximately 3800-2000 rad.
bone
below 800 rad
transplants are rejected.
From
the
and
twin
transfusion of
abuve as an
from
.
transplant.
is
bone marrow tror his
indication
for
the earlier discussion
experimental
the
ot
conditions
where
uniform wnele “ody distribution of
icentified.
Although radiation dose
oe
oe.by radtatio
n ,
a0
ne (51-54),
transplantation,
the
was
the
depth-dose curves sea
Jjuses
used above were
delivered
ie
in a
absorpec enerpy.
Aare
power,
wees
Wout
a
pee
Segate
-108-
IG |
ay
™ Me
OBETARTareaoe BE ALSSOLE
eeBay
befo
ene ae
has been sive !
et
A genectthe al
twin.
radiation
mouse
-5
Above roughly 2000 rad theseas
irradiation casualty exPoy
certainty anc
the
hours
immunity 15 not sufticient
that doses anc
yy.
requirement that
In ome
bone marrow
7es
ytes
hours prior ;
in
the
lymphocy tes collectea promptly, ‘the casualty w.
the ideal donor.
snown with any degree
the magnitude of
(50-55).
48
marrow transplantation,
have beef HLA-typed and donors will have been
identical
that might
ag
tadilation dose,
no
lymphocytes
bone marrow transplantation will ouly rarely be indicated
irradiation casualty because
dose
&Tanuloc
irradiated with 2U0U rad before
to kill
ji
vive
Production ¢
the granulocyte count
rises above 500/Ll, fever subsides, and eviagence of infection disappears,ag
.
G9,
gta
accelerates
Ss
or with amphotericin may be considered.
£ra
colony-set,
the most likely agent is an organtsm trom nornal bowel
that are
een
niques
indicattoq ~229
tnough cultures are
ema
ad
include aminoglycoside and carbenicillin with <te::
oS
additional antibiotics being adued as indicated by bacterial culture
m Pj
initial
'
Fever with clinical signs of
sustained more
initiating systemic antibacterial
negative.
Aamittedly,
than 38°C should aruuSe strong suspiciun of
the aranulopenic patient.
infection,
a
scale,
Infection is the zreatest threut to life.
signiticant fever greater
for
ere
=o an