to praise ayperpiacia in sae catients.
/lthourh we must admit
that tac iene detine chyroid stinalator (LATS) is the mechanica we anp not covincmed
which [Reaves the
thyrGid 2A Geaves' «ajsease, it is demenstmbie in at least half of thebe puticonts
moter: Seoatnent.
we have the LAGS assay cweithad firmly establishes? infcur Lakzatme-“Se
mltheurch, 13 Beate Agova, Wwe had no of portunity to obtain rediated h aa tht
tissue of “raves! Udiocas? curing tne past
year and to camry aut cur us
thyrsid) Sinsue with sootlal at lenticn to the occurrence of bizarre for
patients, whom the epoertundty does arice we are Prep wv) to see wheth
ap he he “NG Tebova Taw any mbationchip wy the Dbsieres nuclear ferns]
huaweiinveostids.
ARQ LCGGF CUOACHOSOMETD TH CLRCULATTIING LEUKOC
NPN TOLLOWONS THERAPZUTIC boces or llr
Bee
in sea
thea rresermme
$ sand in sco
TES
teak subte strovatieng fnowhis country cn chresacwl ufccallocs ia
cipeuse tains leukeeytes following lerye deses of
Wwhre mela: $ ter this contract.
451T fer carcinoma of
fhe thyreid
These observations were mide ‘ci!lowing a very 292
done of +423. Mot only wag there an acute and markerl rise in the inci
anwralias in chremésoms of the circulating leukecytes, but residual eff
:
form of ancsalies fron previocs massive dosea of 481% nad persistedsSiz spears.
Since thet tim, Vac have attesrpted to detect chromosonal anmelics
treated with the usual therazeritic doses (Five to fifteun mi lLicuries)
for G1raves! disease.
Some publications nave appeared describing changgs
doses of 4447 of this rane, bat from our gradually accumulated experi
3
caused by
has bean wore ques tien of the validity of cenehstens based on simple
observations. we .ive felt that it was necessary to make observaticnslors a love
series af blocd Samples, with multiple culturms fron each, and a largelmrnber =f
peparetions fron each cultur2, along with extensive pretreatment con
to muha sucn cbservaticns valid. bavid Satcher, an M. D., Ph. D. candi
SONNE
under or. leil Macintyre (with when we published the first work), hes
Fecn stvfans
this probien of ‘chresesonal aberrations in sere of the 1511 treated pa
were studying in detail. Althouzh he has studied relatively few cases
them in great detail as implied above.
this thesis entitled, wane Effe
Aeradiaticn cn the Chrosesomes of Feripheral Blocd Leu?kocytes™ > has j
end his dezrees are being awarded. He has studied the effects of dose
from 6 to 19.7 me. An increase in the frequency of chromosomal aberra
which reached a peak at 24 hcurs and fell to almost control levels by
treatment.
Se has not found a relationship between the dose of lslri
increase in frequency of chrescsane aberraticns in time.
Some patientg
h=ve
=
greater mspcnse than others without a readily available explenatio.
from the ccse-respense curves for aberrations that only leukeeytes al
streaa at the tine of 1-4] therapy were involved and that precursor ce
Significantiy canared. He has very carefully analyzed a suspected
ce of exrcr st
may have contributed <9 misinterpretations of data produced by scme otiiers. T=
queséscn a3 lcogicall, raised «hether the i3ly Circulating in the blood
sample 15 taken and <ransferred to the culture contributes to the ci
while these cells are in culiime. To testthis question, a goodly a
was cbtaincd from the patient tefore the 1slr was administered. This
serun was then substituted fer the patient's radicactive serua «hen
tomes were
preparcd subsequent to giving the patient 131;, Conversely the hot”
to pretreatment control cultures.
It was shown that residual 4311
culture continued to damage chromosanes while the culture was in p
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