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Errors in Human Hemoglobin as a Function of Age
2i3
Table I. Substitution frequency of isoleucine for other amino acids in human hemoglobin from 25 Marshall Island people and 3 ORNL laboratory personnel
Sample
Exposure
Ageat
exposure
Ageat Sex
present
Substitution
Average +
frequency (x 10-5) SEM (x 10-5)
years
NTS
15 months 21
175
30 years
24R
33R
35R
42R
WIR
175
175
175
175
175
l3 years
1 year
}2 years
2years
27 years
6A
69
44Q
8669
1gsR
8A.
45A
SIA
813U
815
829U
836
839
B41U
846
867U
B68U
944U
1547
1549
EB
WL
RAP
8360
8368
867Ua
867UB
$68Ua
868UB
175
24 years
M_
50
M
33
21
32
22
47
F
F
F
F
F
44
F
3.58
5.06
21
3years
23
Tyears
27
F
0
0
0
0
0
0
0.
0
0
20
24
35
41
46
41
51
46
51.
M
M
F
M
F
F
F
F
F
3.37
2.57
3.47
2.45
1.89
3.56
2.41
2.12
4.35
0
60
F
7.15
34
M
17 months
69
31 years
«69
0
0
0
0
0
21
51
49
21
45
43
6.98
F
12.93
F
3.65
M
M
M
M
M
‘
13.45
4.74
5.19
10.40
8.29
1 year
69
M
,19.79
4.04
i
8.81 £1.96
)
_-5.941,92
2.12
“
oo
3.20% 1.52
|
3.93
1.57
2.84
4.37
3.36
|
43.5240.45
|
‘
Soy
a
.
we
a
.
;
.
s,
OS ws
So
2.05
4.41
1.99
3.40
1.76
5.04
m
+
3R
10R