:f
Bn
Ay tt Bee ae ceo abd Rte6 o
weer ie RS ito bene SO
beaters
SAAR
Ove 6
puoteiiy
net
together
nrogress of planaed can de conipleted.
cos et rehetons from ra abe ath
Wingar extrapolation with no threshold. A
plotting
.
.
linear.
Anotker wee OF the imensive study of ttoseTesponse Telatiens for radiorecent use of the 7 “dou Ming tos Scopcenn Tae wos develoored
nuclides is 7
teat! ida stgmectd one. Tamplin & Gofmar
the only one that fits the beagle-dog dats
a difference between the alpha and beta or
siatvsis Suggests. the direction is consistent
tate recovery from effects of the two kinds
“tons may be just as valid.
to Bundleos gsembing the genetic effects oF radiation and /s specifically the
dose regain. (2 dounle che ine dune cate of oo given mutauen. (NOTE: Sume
other ge uu :'Teets may rise as the square of the dose or by other functions).
The conce; 25. very dependent! upon the pattctiar kineties of the genetic response. esr. . car, cumulative. ete. Same author: (143, 151) have applied this
-s differ with the model is seen in the analys’s
concept ty core nogenesis induced by radionuclides as well as by external radia-
1000 rads the projected risk (in man) in 50
tion. Fur. arcental to the argument is whe:hsr or nat ‘increase in incidence is
~ -upads for a “low-dose linear model” and
1a dose squared model. Thus the differer.ce
vred Rosenblatt (146, 147) utilizes a three.
4-40 account for simultaneous contribut ons
2 ancidence in beagles receiving radiury or
« utler-Ederer life table method (143. for
Baan atisoue. This logis ic type respe tse
ats age-related incidences to be calculated
in propor ut to normal iaciklence ries o7 on ar tsolute basis. While the data
brows $ caar are prime’ dy tor extorael n.d. iga, an [CORP analysis (157)
doesnot. wcagralsupper. setorre: siew. 7) akes considerable difference
to the pre fon of risk froun the tovaily of veriecas forms of cancer induced by
radior vcuits,
Bla: (0 o nes used the dost oc. nectar nd Cen for radionuclides as a tool
for im .c 2 generac meychan sm. ae front ceera studies €153, 154), the last
ota
as
pe
Pe
nero se ie beagtes. “kin
Heme OR ee rete sity
redm. 7 f Stoers, Newman & Altschuler
9°
“aan incidence would occur at age 50 in the
(iSi3, a: lang cancer ie uparhaps
at
“af cone tumor in mouse and dogreceiving
See outs, teurers a much bot or inn aun
,
kee
is vie. ba cer case he Concindes that there
long wath risk evaluations based on it, by
peree a ke ber uy tedeton, One, char-
Boe Pig crass do Gareet © fall Booey wgenebh. the ather, characteristic
dee.and Folles¢ onlyafter a long
‘yg Square of the number of beta particles
«Rody weight. This did not appear to hold,
oy venerabzes that the data froet mouse.
AUD fiero. Dic uses averaugiu -«elial dos from the ocvecal bone-seeking
nuclides iy the dogs, applied betu-radiation dose in the rats, and the inferred
lune @o 6 fy vaicuiation back frou messuicd 7'°Pb costed of bone in the
soentaltly equal radiosensitivity of the critical
‘olsen: ts! ohenomenon.
urnuat Ps ide, 5
oh Vie hb Yosutics Corstinii doxw-cale. wih is cerWV Or pot oa bs a besser a
ba da Ovens Caturibg suuplificaven of the
et 4) 437) the linear nonthreshola model
Gib len. Mg aeses athe a. dsr tik Galen wasies Gat ih raters
wavadeads per person-rad regardless @"
paroboy tee dose dary
bes not. th
Afie-r
fects ob ragiaion wthoueh ws ponereih
oie
‘Tr oaluest never anpesis im wrervecs!
. 7
é
ta
"
chee
6
TSE TL at yt
nee
tts
(ga
Sate tore
Blairs
concert
and
re
ces phagesrome Anke are
Sp aMeeg ys Fewer GQ OMe Po went CF Gee lkae
.
Ae! lop see predpeecnszca cisadip.-oe oat hive cellectively accumulated the dove.
.
aye
«SBR 6h AEELer BETERNBRC Hote YY eae.SPTaren epeemaTRNN
rdog ayPEREORRem rte am endgi gt bog,
co orien Ph irapitieeeineee
ag
ee
‘
,
.
wo
te
Feros re BRE
.
cro
.
L
,
rare
,
EE
tte
or cs
BEE Bee RR a
.
o
reo iss oon tart far een tumor repe,
Gonna
nn
pete
gpb
y
x eee
SABES
ke3 Hee
:
Cae er.
wal UN,
wee OM
derils al the suarther of
- Vast none of the studies. man er anit
r
‘
a san five aosmorions usually
.
|
¥
Contrast, the analysis by Mays et af (79) cf
“rc fe'ytonium, radium, ete.) shows a better
-
eee
SIEMOK! Lo oOPsmip seen MM a tac bvery PC eecous aN Pepa don
scat of expostire to cartroutiny
of
(homegenevts wna terms tot oris
facters. ev vlreament. care. eto mas refleet rrimerily tne relating identity of
;
.
‘e
:
thresholds in coat popuiation, thresholds mug vi vary much more ona highly
heterogeneous. Suman populaden and the relation be fess sigrncid and rrore
af padiostrantium and radiacalcium in
at fata, dees not fit the dose-response
i dow closes there is always a lower incidence
) canased group, Th
f
spurious!: =war, ret He alo cubs attendon io the ievpertant tact that a
Gass & Lioyd CLIO) summarize § extensive
oes
.
re
.
the e scoticr cf the data, Abolas Causes chide bos cegentis ported oul
yte 2settled to even
haute sumapcantiv. and show clearly that
a
1
:
in shape of The Sumves fitting argue’ ove the ar bet aye fies wand oss than
con .
A full-blown
flaw dose domaip.
rene
s
a
.
a
aca
Iwihte
‘oa,
sats bre Ubeaeilde a otaa
345
ee
cee
epi ee ab eb ee
-sean geither oe supported vor retuied without
ae te
“fy
7
kates
TORICOLOGY OF RAD SUCLIDES
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