ORIGIN OF RISK COEFFICIENTS
I. BEIR-I
A. Cancer (Tables 3-3 and 3-4)
BEIR-I
Derived
Cancer Deaths/year in U.S.
from 0.1 rem/year
Cancer Deaths/106 person rem
(pop=197,863,000)
Absolute
Relative
576
738
30 year elevated risk
1,210
lifetime elevated risk
1,485
Leukemia
Absolute
Relative
26
37
2,436
61
123
8,340
75
42]
3,174-9,078
87-101
160-458
.
Other Cancers
Range
1,726-2,001
B. Birth Defects (page 2)
5 rem/30 years ————®100-1800 cases of dominant diseases and
defects per year (3.6 million births/
year)=0.05% incidence per year
(5 X this at equilibrium)
In addition--a few chromosomal defects
and recessive diseases and a few
congenital defects due to single gene
defects and chromosome aberrations
Total incidence is 100 to 27,000/year
at equilibrium=0.75% at equilibrium
or 0.1% in the first generation
Overal] il] health:
5% - 50% of 711
health is proportional to mutation
rate
Using 20% and doubling dose of 20 rem,
5 rem per generation—* 5% increase
in i1] health
5%/5 rem in 30 years at equilibrium
or 1%/5 rem in first generation = 0.2%/rem - 30 year dose