-2=
This
of 4njury and the clinical manifestations are croportionate to the dose,
4s particularly true of the syndromes of w).ole body radiation.
I repeat, highly dependent on doseand time after exposure,
description.
The latter is and
There is no simple
The problem is subtle and complex and one must always bear dose and
time in mind.
THE SYNDROMES FRCM TOTAL RODY PENETRATING RADIATIONS
The dose dependent symiromes resulting from total body exposure in the
mammal have been described in detail and I shall only simmarize them here.
further details one is referred to the following references (1-12).
For
After
large doses (approxinetely 6000 r or more) the central nervous system syndrome
wi4ch can be aboreviated CNS is produced.
being irradiated or after some hours.
Death may occur under the team while
“he clinical picture is characterized by
hyperexcitability, disorders of equilibrium, incoordination, respiratory distress
and intermittent stupor.
Convulsions may preceed death.
this syndrome are always uniformly fatal.
Doses capable of producing
If an cccasional enimal, and presumably
man, survives this CNS he has yet to experience the gastrointestinal syndrome (GIS),
which when produced by doses in excess of 1500 r is always fatal within three to
nine days for mammals,
laboratory animals,
Presumably man also will respond in a corparable manner as
The GIS is so named because of the marked nausea, vomiting,
jarrhea, and denudation of the lining of the small bowel,
fatal syndrome in most laboratory animals,
The GIS is a unifornly
If the short duration GIS of a few hours
resulting from lower doses, does not produce the three to nine day death, the survivors of this syndrome have yet to experience the sequelae of bone marrow depression
which has been termed the hemopoietic syndrome (HS).
The HS 4s not necessarily fatal.
It is the clinical ricture that is seen in the lethal range for all mammals and in
general the 50% lethal dose values reported, represent the Lp°0 for the sequela of
henopoietic depression - namely granulocytopenia, depressed defenses ageinst infection, -thrombopenia, and anecia with the pcssible resulting infections, diffuse pur