- 31 a burden range of 0.5 uCi
fluctuated between 0.04
|
-
to 50 uCi the observed tumor incidence
51
and 0.37”.
All of these lung cxperiments involved intense exposures
and a significant level of carcinogenesis.
Severe damage
and disruption of tissue were associated with the exposures.
The most relevant lung experiment is Bair's Pu 3905
inhalation study with beagles>*7 4,
Exposure was
to
particulates of 0.25 u or 0.5 u median diameter; burdens were
in the uCi range.
Twenty of the 21 dogs
that survived more
than 1600 days post exposure had lung cancer.
cancers were multicentric in origin.
Many of these
The cancers again
appeared in conjunction with severe lung injury.
natural incidence of the disease is small,
Since the
it appears that
at this level of exposure the induction of lung cancer is a
certainty during the normal beagle life span.
S1/
Cember, H., Op.
cit.
$2/.
Bair, W.J., J.F. Park, and W.J. Clarke,
At the same
,
“Long-term
study of inhaled plutonium in dogs," Battelle Memorial Institute
(Richland), AFWL-TR-65-214, 1966 (AD-631 690).
593/
Park,
J.F.,
W.J.
Clarke and W.J.
Bair,
"Chronic effects
of inhaled 239pPu02 in beagles," Battelle-Northwest Laboratory
Annual Report for 1967 to the USAEC Division of Biology and
Medicine, Vol. I, Biological Sciences, BNWL-714, 1968,
pp.
54/
3.3-3.4.
Park,
J.F.,
et al,
"Progress
in Beagle Dog Studies with
Transuranium Elements at Battelle-Northwest," Health Physics,
Vol. 22, No. 6, June 1972, pp. 803-810.
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