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APPENDIX B
Sr and Ca Metabolism
‘ene.
1...)
2..
reeof
Method of admin.
24 hrs......|
I.V (lactate)..J]
Age at admin.
Animal
.
Mice... .}..0-2.-. 20-4.
Adult.......
Mice.....
Rats.....)
Approx.
weeks,
5
48 hrs......
9-15 days. .|
3days.....
Growing.....
23%
Injected......)..........)........2...
13-31%
53-65%
0.4
Oral (lactate).| 0.5-2 mg.| 1.5-4mg...}
10%
15%
0.7
Oral (lactate |...do..... 12 dO....00,
15%
381%
0.5
‘11%
28%
0.4
I.P
.
(lactate |..........]...re
Carrier
free,
..d0....,
Adult... 2... dO. feces ...d0.....
(Low Ca
diet).
(High Ca
diet).
(Low Ca
diet).
dow... (High Ca
i ee ...d0....,
SGATHOUY BOC
8 weeks.....|
re eet hye:
eae!
1...
73%
17%
;
.......
16%
.......
.
Rats reared 15~—20 days (shortly after weaning) on Ca de-
ficient diet then treated.
0.6
Effect of dietary Ca on Sr retention is apparent, though
data not quantative.
Lees
Lees
2.8% .......
|
Similar results, ranging from 70% Sr reten-
(high Ca).
70%
Intramuscu- ].......-.-|...........lar.
65%
4 days...../..... do....... Carrier |............
free.
81%
Lday...... TV cc cele fee eee eee
81%
3 days.....J..... GO. lec lee eee eae
67%
10 days....|..... 7, ee
55%
30 days....|..... GO. ccc le ccc ene fence eee eee
72%
8 days..... TP... le... Carrier |,...........
free.
|
Rats.....)...-..05 ....-|
etry.
diet).
4 days.....|
50 days.....|
50 days.....|
Rats.....
45%
‘26%
ing period of retention.
tion in young (low Ca) to 14% in old
adult.
Rats.....
7
males which gave birth dur-
vita-
min D).
Oral.........
,
Growing and |...do.......
tate, gluconate essentially
identical.
These mice were pregnant fe-
.......
I.P (lactate). .|...do..... ...d0......,
4days.....|
0.8
0.5
IV uptake of Sr chloride, lactate, gluconate essentially
identical.
Oral uptakeof Sr chloride, lac-
Leas
1.6 mg..-..|
with vitamin D).
Comments
oerat
|... een
38%
1.6 mg...j...........,
|... 0...
45%
0.017... J... eee eee.
58%
O.8 mg.....f.........
11% j... 0.024.
Oral (lactate) .[..........[-.......0005
with
Rats.....
”oate
“Stre
Ca intake
Sr intake
.
:
.
:
81%
0.9
Sr and ‘Ca in different rats.
75%
0.9
86%
88%
87%
79%
.......
0.9
0.9
0.8
0.7
Sr and Cain samerats (double
tracer).
Ra studies carried out in same
series; retention at successive
periods 73%, 58%, 55%,
53%, respectively.
73%
Fe
Rp reeis
ER
24:
1
.
TT
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