39
row examinationswill be carried out in both these
Bone Marrow Examinations
The differential counts of bone marrow aspira-
tions on 6 individuals, 4 exposed and 2 unexposed,
are listed in Appendix 18. The differential counts
showedthat in 3 of 4 exposed persons there was an
alteration in the myeloid-erythroid ratio manifested by an increased numberof red cell precursors. In addition to hyperplasia, abnormalities of
chromatin material with double nuclei and increased numbersof mitotic figures were seen in
the normoblastic series (Figures 50 and 51). One
of the exposed (No. 63} and one of the unexposed
(No. 948) showedincreased lymphocytosis of 33%
and 27% respectively. This was reflected in the
peripheral blood counts in which the total number
of leukocytes was normal but the lymphocytes
were increased to 51% and 56%. The significance of
this finding remains obscure, but repeat bone mar-
cases during the 1965 survey.
Red Cell Mass and Plasma Volume Studies
During the 1961 and 1962 surveys blood volume
studies were performed on a group of Marshallese
subjects and on a small number of Caucasians
who had beenliving on the islands for one year or
longer. Sodium chromate labeled with Cr*! was
used to tag the erythrocytes. With body weight as
a criterion, it appeared that 15 of 23 subjects, both
Marshallese and Caucasian, showeda significant
reduction in red cell mass and/or plasma volume.
In orderto establish the relationship of blood
volume to lean body mass tritiated water was
administered orally to each of 21 Marshallese
subjects during the 1963 survey. In addition, determinations were madeofred cell mass and blood
volume by using Cr’'-labeled sodium chromate.
Table 20
Total Blood and Red Cell Volume Data
(WT.=gross weight; TBW = total body water; FAT=fat as % gross weight;
LBM =lean body mass; RCV=red cell volume; BV =blood volume)
Subject
No.
WT.,kg
TBW,!1
TBW,%
FAT,%
LBM,kg
RCV,1_
BVY,!1
RCV/LBM,
ml/kg
BV/LBM,
ml/kg
822
832
836
838
841
873
881
882
885
895
916
928
932
938
942
“959
960
1007
1043
1501
Jeton
54.54
46.36
56.36
66.13
66.81
61.36
68.63
54.77
61.81
55.90
63.63
57.27
46.30
40.00
57.72
60.00
38.63
71.36
41.81
66.81
63.18
38.1
25.0
35.3
41.7
31.9
43.2
32.8
39.9
41.0
29.0
32.6
29.4
26.2
22.0
27.6
32.2
24.8
41.2
26.4
43,3
39.8
33.5
68.8
53.0
61.7
62.2
47.0
69.4
47.1
71.8
65.3
51.5
50.4
50.5
55.7
54.1
47.1
52.8
63.1
56.9
62.3
64.0
61.9
44
26.4
14.3
13.6
34.7
3.6
34.6
0.3
9,3
28,5
30.0
29.9
22.6
24.9
34.6
26.7
12.4
21.0
13.5
11.2
14.0
52.1
34.1
48.3
57.1
43.6
59.1
44,7
54.6
56.1
40.0
44.5
40.2
35.8
30.1
37.8
44.0
33.9
56.4
36.2
59.3
54.4
1.402
0.849
1.428
2108
1.150
1.670
1.996
1.131
1.760
1,070
1.091
0.927
1.274
0.886
0.860
L151
0.774
1.620
1.066
1.843
1.310
1.303
3.260
2.358
3.320
4.053
3.196
3.631
4.247
3.426
3.825
2.488
3.031
2.505
2.963
2.331
2.150
2.877
2.150
4.155
2.664
3.840
2.675
3.102
26.9
24.9
29.6
36.9
26.4
28.3
44.7
20.7
31.4
26.8
24.5
23.1
35.6
29.4
22.8
26.2
22.8
28,7
29.4
31.1
24,1
28.3
62.6
69.2
68.7
71.0
73.3
614
95.0
62.7
68.2
62.2
68.1
62.3
82.8
774
36.9
65.4
63.4
73.7
73.6
64.8
49.2
68.2
Ay
Av RCV (1)
AVBV(D)
TBW(12039)
PBW 22-022