ro UNCLASSIFIED GENETIC EFFECTS H. The nature of genetic effects: data evidence, experience, J. Relationship between radiation and change in mutation rate 1. Natural mutation rate (2%) 2, Dose necessary to double mutation rate (50 r) 3, Apparent linear non-threshold between dose and effects f relationship 4, Cumulative character of genetic effects 5. Mechanics of introducing and eliminating mutants in genetic pool K. Predicted increase in mutation rate as a result of postulated increase in radiation levels from fallout 1. Effects on: population whole as individuals and as a METHODS AND STANDARDS OF RADIATION PROTECTION AS APPLIED TO FALLOUT PROBLEMS : L, Standards for external-radiation effects: the concepts and definitions relating the amount of damage to the amount and kind of radiation causing the damage 1. Definitions and concepts behind the units used for dose rate, cumulative dosage, biological effectiveness, etc.: the r, rad, rem, RBE; ionizing density; linear energy transfer ~ 2, Kinds of radiation and varying conditions of exposure 3. Simplifying assumptions to get practical standards 4, Caleulation of dose and dose rate resulting from several kinds of radiation acting together 5. Calculation of doses and dose rate resulting from one or several kinds of radiation acting on different parts of the body M, Standards for internal-radiation effects 1. Definitions and concepts behind the measurement of internal body burdens and dosages; the models used a. Maximum permissible concentration b. Safety factors - 19 -

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