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PRIVACYACT MATERIAL REMOVED:2 =o=
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studies. because they would, producevery low
radiation dose ;. yet the’ specific activity’of plasrha
(bodywater)’gavea‘countingrate‘thatwasjgreater
thanbackground by’afactor'of20tg30."
Dosage rate and total dose werecalculated for
a 70 kilogrammanusing anaverage betaparticle
.aseeeaes
ectedin
entage ol.
a
teSoo
an ei Nae
ok fedaeive
ws
“aE
-
yet,
mt
hee
iidOFF
data‘toatablih
a,reliable
Helene,andage., Tt:is,felt
that'such’s cortelation would, inany event,be.¢s-
sentially& correlationbetween fatand age.
‘Since’ individuals:differ, markedly in degree of
obesity,the: proportion of body water normally pres-
entwill?‘Wary/accordingty andthus’may ‘imask any
positiveindicationof altered waterbalance.)Body
.waterdeterminationsindisease states consequently
appear tobeoflittle -value as a quantitative measure of-water-retentionor deficiency unlesstotal fat
calibe determinedindependently. AsSteele, Berger,Dumhing,and: Brodie (17) have alrealy:stated,
an‘obese‘person.can develop edema. and still haye
a smaller: proportion of body water than‘a- lean,
‘nota individual,. .. This. explains the lack of a
significant,difference . in the proportion of body
water observed.in cardiac patients with and without: edema, shown in Table IV..
pols
_The‘average percentage of total bod), water. of
Group. A,.(Table V), ‘whichtonsists whollyof feance of tritiumwith'ahalf life of 10 days.""*
The, maximum! dosage rate,|whichwouldoccur males, was 43.5%.as. compared to44.6%.for, norat the time, ‘ofinjection, is;“dosage. rate=(2) mal] females (17), In Group B there arefive male
(37 x 10"): (6,000) (1.64:x10)/(70):= 0.01 patients.‘with an. average. body. water. of. 55.2%,
rep./day where 37° 10"is the’numberofdisin- which js, only, slightly .higher.than our ;figure
tegrationspermillicurie’ssec.,-and1.6410is a (S2.1%)‘for svSrmal males. The two femalesiin
factor forconversion.from‘electron‘Voltsper sec- this: group had total body waters considerably
ond to roentgenequivalentBhysical(rep) Per.coy. above the averagefornormal females.
' Little emphasis was placed: om:the :measurement
assuming 84ergsiper.rep. *
of
body water.turnover in. this investigation because
Total dosewas calculated bythe formula:
of previous:work on‘this aspéctofthe'problem by
energy of 6 kilovolts and an éxponential disa
Total dose==dosage rate>halftime/In2=z,(0.01) Pinson, and Anderson (12). Thesé'linvestigators,
Lo
- 0)/(0.653). =0.14 rep, using fridia,found. biological ‘half-lives’‘of body
which represents the integraitinofthedéesze rate
waterineight normal subjects onan ad libitum
from the time of injection to infinity. ‘The radia- water intake to range from nine to 14 days. These
tion dose during the first week is considerably less | values agree closely with those found by Schloerb,
than the generally accepted tolerance level of 0.3 ‘and his associates. (11) using deuterium. When
the water intake of one of these individuals was
roentgen per week.
.
tet
%
9043061
a.
F
PRIVACY ACT MATERIAL REMOVED