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Fic. 2.—A, Starch gel patterns of isozymes of lactate dehydrogenase from Micronesian
samples showing the normal (slots I and 4) and “Calcutta” like phenotype (slots 2 and 3).
B, Polyacrylamide gel electrophoresis of serum transferrin from normal individuals (slots 2, 3,
and 5) and individuals of the transferrin CB phenotype (slots'2 and 4).
-
have reported the transferrin CD phenotype in Micronesian populations, the CB
phenotype has not been previously observed. For none of these three individuals
were the parents available.
DISCUSSION
Gene frequencies for the 6 polymorphisms encountered all fell within the range
reported in other studies of Micronesians [13-20].
In table 1 we summarize not only our own findings but also the results of all
the other studies of rare variants of 25 systems in Micronesians which we were able
to locate in the literature. To date, 27 islands have been sampled. Any effort to
treat “rare” variants involves some arbitrary decisions; no approach is apt to find
universal acceptance at this time. We excluded from this summary any variant
which, for the totality of the representatives of the population studied to date,
occurs in more than 2% of the group (one of the conventional definitions of a
polymorphism). By this definition of rare variant, we excluded from the tabulation
the polymorphisms involving types 3 and 7 of the PGM, system reported by Blake
et al. [13] and the polymorphism for the type 2 of phosphoglycerate kinase reported by these same authors. The final column of table 1 presents the frequency
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