TABLE 37.
_
Lymph
Oncan Distrinution oF #?Th 1n Man FoLLowIneG INTRAVASCULAR ADMINISTRATION OF THOROTRAST
Author... -. 02ers ee eee Hurshet al.(@)
nodes
Kaul
Rundo
ANL group
Parret al.
9
6
3
11, 17
This paper
4
Several
9
2
6
Duration .....-.-..255-
17d-19y
Long term
Long term
(mean 12y)
18y, 26.5y
26d-26y
Method of analysis. .....
comity
analysis
analysis
@-ray analysis
analysis
Reference... 1s. seen ee
_—-——_——
Kev of caseS.-- 6... ee eee
~
3
960
Mean values
fcolumns 2-6)
Fraction of body
burden in
organ :‘¢)
10041/144,7
percent
—_———
fi
————f
'
Liver
spleen
Red bone marrow
Lung
skeleton
Adrenal
Heart
Intestine
Kidney
—_
Muscle
Pancreas
Thyroid
100
9
8
1.8
0.75
0.003
0.07
0.6
(52)) 100
(17)
33
(30)
(0.8)
58
(71)®
(17)
(<12)
1.2
100
36
100
<17
(0.55) © 0.8)
0.18
100
18
11
' 0.4
4.1
0.13
5
0.05
0.05
Total
100
24
12)
1.1
1.7
0.003
0.07
0.6
0.15
5
0.05
0.05
144.7
69
17
8
0.8
1.2
0.0029
0.05
0.4¢°
0.1
3,5
0.0366
0.03)
100
“ Liver, spleen, red bone marrow and lung figures are from authors’ ‘‘preferred values” for 3?Th concentrations in these organs,
based on 4 patients (17d, 49d, 18y and 19y burdens). Other figures are based directly on quoted #2Th concentrations (18 and 19y
simplest’ burdens). Organ weights in standard man assumed.
imes thee
‘” Quoted distribution as percent of whole-body burden.
erties off
(? Normalized with respect to the liver content assuming liver burden to be 70% of whole-body burden.
“) Weighted mean value, using weighting factor of 0.1 for results of Rundo and Kaul, which were not based directly on measure-
is paper.fr
‘nts of separated red bone marrow, and unit weighting factor otherwise.
she basis:
" Excluding organs not listed (particularly lymph nodes and perivascular deposits, which may contain a significant fraction
fof the injected Thorotrast).
‘8 Measurements to be interpreted with caution as they are based on only a single analysis.
tion of °8°Th among the various organsof the body, so
revealed (Table 36) is in general agreement with the
can be made on
itions inresults of other workers. A comparison
i
acentraedth basis of the data presented in Table 37, where, as
n Tablet for Table 35, normalized values relative to the conre 2827,RCCNtration in the liver, are quoted. The results sugthe ma-feC"! that the major part of the Thorotrast (~95% of
y, some thet contained in the organslisted) is taken up by the
olations £20" !oendothelial system, and that it is distributed
between the liver, spleen, and bone marrow, approxi> due tok
an, Un ma.‘tely in the ratios 100:24:12.
sample}
It is important to note that the percentage values
larly in fisted i3 n Table 37, last column, refer only to those orin thet Bins listed, and notably they neglect any considera-
s basis, jtion of the lymph nodes. Reliable data for the lym-
rat are Pltic system are almost completely lacking, but the -
factivities quoted for patient 166 (Table 35) suggest
35) tof thet theTh concentration in certain lymph nodes
, organ B' ¢xcced that in the liver by approximately a factor
ith the 0 0. It would be not surprising, therefore, if a sig-
istribu- Mic“tnt proportion of the whole-body burden of 73?Th
were to be found located in the whole lymphatic sys-
tem.
Consideration has also been omitted from Table 37
of the activities located in perivascular deposits at the
site of the injection. Such deposits are indicative of a
poor injection technique. External measurements of
Thorotrast patients in Vienna by whole-body profile
scanning have shown that the proportion of the total-
body radioactivity (of *°°T1) so located, not uncommonly exceeds 50%. The perivascular deposits deserve
a separate study.
Considerable caution is called for when using the re-
sults of Table 37 to predict the distribution of *8?Th in
any one Thorotrast patient. Particularly for the liver
and spleen, wide departures from these average values
—showing no obvious correlations with variables such
as the age of the burden—are commonly observed in
individual cases. This is evident from the data of Table
35, though undoubtedly here, sampling problems were
partly responsible. However,it is also certain that real
differences exist. Thus, in a series of 15 patients,