( ss sonceranvars‘ashsanlagssaeilablaap CONTENTS Some Studies of Immunological Aspects of Aging and Fallout Radiation Exposure........ 31 Materials and Methods... cece eseeseeeeeneretenreneenenees seecceecacaceecegeeeaeeaeeesiseueeessseetetaeenens 31 Lymphocyte Cultures... cece seen cece cena ences eeneesaescetseaesnencesesseua gene caenasetierenea 31 Serum Proteins... cece cee cseeeneeeas cone cecesneescsteesesenecenetececaeeeenssaeaenesseeeneeetavesenscaa 32 Serum Immunoglobulins... cc cceeecesceee ceceeeeseceersesaesesesevensesoneesvaesesessaeeeeeseeseneeaseees 32 Peripheral Blood Element...000...0.0.0..:.ccccsccscsesssescessereeeeteneneessesesese senses sasecasenenetieeeseats 32 Statistical Analysis of Data... cceeessrceeeeeceeeeeteecseceneseceseasseneresenseeescaeaauenseaeersees 32 Results... ieee ceece cece ceeeceeentes seeeeeneseceenesaesssenesesesveseeconseeaeensteeassnteenaespanecseeesieecaeseses nants 32 . Response of Lymphocytes to Phytohemagglutinin Stimulation......00000..000 ee 33 Peripheral Blood Element...0.....0...c.cccecssecseeseeecescoseesensneasesssasecesscenseneeeasaceavenseseseeeseanes 33 Serum Protein Patterns... .cccecsceseesceeestseecescseeseseseneceseevecsessuessnenscaseteeeesasssaeeesueasies 33 Discussion... cceeccseeeseseseseteneceas nesesssevese cececeeseneeenaeeseseececerstsseveussaneessanavereneueveeseneeeesieeeaes’ 37 Estimation of Internal Body Burdens of Radionuclides in Marshallese.........0..0.0...00c08 39 Hematological Findings...0..........0.cccsccscecseeseeeeeeeesee cece cereeessceneseessenesnsssuecetseeeastaseeneesiceaeesys 40 SummaryoF Finpincs in RonceLap PEopte OvER THE PasT 15 YEARS..........:ccccceeeeeeeee 43 Prodromal Radiation Effects..............cccccsessssssesescseseaetoeeessscneserencecasnencaeesuanseeeetevesseenasseesnenes 43 Acute Effects... cece eececseaseessensenessesseseauessese sonseesscaecseaacsnsecesassseesdvasaseeeneaasaesecasreaceesees 43 Penetrating Radiation... cece cesses cso eerecaeenteerenscaceauen seseeaesseenseaecereceseceesaeseersesies 43 qs —— ce fad a = C51 Beta Irradiation of the Skim... cee cece see seeeeceetensse ress seseneeeserseseeassseanaceeneeeeeneneets 44 Internal Irradiation... eeccceses cece ceseecesceeecoesceeetenecscaeseeese cassetensaeeeaeaaeeecsesaeaneneacees 44 Late Effects... cee cecetseecseseseseeseseeeseeccesecnescnevsceeseeessenevan saasseaeeeesasecsssanevacsesesnesseeesasnesanetnenaees 45 Gemreral Healthn....... ccc ccscecescec rece sreeeneseasseeesseasacscenececeecscsvensaeesseeseevensesaneceessanetsen aes 45 Mortality... cccccccceeceeseseaeee sees cesesesesteaceaesuneensssesecsesceqeseeeseneasesevaseeecsnecens sesepacesenevanee 45 Fertility... cece ceeesee cee ceee sees acee cana tee sees sceeeececseesesasasscereseateneqeenasereeeeeeegersseenenee sete 45 Miscarriages, Stillbirths, Genetic Effects......0...0.0..cc. ccc sees es csetecseecseneeneeeeeeeeteneeens 45 Iv