Table 16 for Unexposed group mutede lean per- standard dy-agar 1eration t of the ‘shallese . Leukoonically cre done of leuko- t stained “the mirates by alysis of ‘Ss among ‘e. These na high ices were females inalyzed f signifi- osed and as deter3 “signifi- e 16, and ytted asa ee Oe+ GIRlpgatlel adap -nsforma- Exposed group Criterion Change with age Correlation with age (r value) Percent dif. from unexposed Lymphocyte transformation D 0.89 -— il 0.68 35 — 15 24 37 —31.0 01 a OAT i STE Correlation of Criteria With Age and Radiation Exposure (D = decrease; I =increase) Serum proteins Total serum proteins ~ Albumen Total globulins Alpha-1 Alpha-2. Beta Gamma Immunoglobulins A (IgA) D (IgD) M (IgM) G (IgG) Kappalight chains Lambda light chains K/L ratio Blood findings Hematocrit Sedimentation rate Total leukocytes Lymphocytes Neutrophils Platelets I D I 45 98 I 43 I I 32 Significance ( p value) +15.0 -17.1 01 .O1 — 20.0 OL 715 6.0 — 18.3 .03 I I I I I 49 .20 .20 .78 96 —17.0 — 3.0 — 40 — 8.0 — 3.0 .05 98 74 22 .69 D I D D I D 7 72 43 91 A4 .65 + 29 +11.4 — 25 — 0.1 —13.8 — 8.4 07 08 59 1 .04 .04 I I I function of age in Figures 34 to 37. Most of the changes generally reached a maximum in the 40 - to 50-year age group with little further change in the older groups. Therefore most of the agedependent correlation was dueto differences between the younger (15 to 50 years) and older age groups (>50 years). 24 41 — —14.0 + 0.4 01 AS 74 response to PHAstimulation ( p>0.68). Peripheral Blood Elements. The changes in exposed population the decrease in lymphocyte levels showed the greatest correlation with age (r=0.91) and appeared to reach a maximum in the 50 to 60-year age group. Slight depressions in platelet counts, white blood counts, and hematocrit were noted but wereless strongly correlated with age. An increase in sedimentation rate, however, wasfairly well correlated with age. In the exposed population the meanlevels of neutrophils andplatelets were significantly depressed ( p<0.04) below levels of the unexposed population, particularly in the older age groups. The other blood findings were not notably different. Serum Protein Patterns. The results for serum proteins determined by electrophoretic analysis are shown in Figure 36 and Table 16. A slight increase was noted with increasing age in the unex- presented in Table 16 and Figure 35, In the un- nificant. The gammaglobulins increased signifi- Response of Lymphocytes to Phytohemagglutinin Stimulation. The transformation of lymphocytes into blast forms as a result of PHA stimulation in peripheral blood cultures showed a decreasing response with increasing age (Figure 34) which was well correlated with age (r=0.89). Lymphocyte cultures in the exposed group showed nosignificant differences from those in the unexposed group in various blood elements as a function of age are 30662490 posed Marshallese, butit was notstatistically sig-