21 CLINICAL OBSERVATIONS AND TREATMENT Table 2.2—URI and Changes in Granulocytes in Groups I and II gitis with prominent lymphoid follicles, fever of 99-100° F. during the first day, and a puru- lent nasal and tracheal discharge for about 10 days. It was of interest to determine whether the appearance of URI could be correlated with the dose of radiation received or with changes in the leukocyte count. Fifty-eight percent of the individuals in | NUMBER . VIDUALS 7 URI, rise in granulocytes__.---..----- | URI; no rise in granulocytes_._..----No URI; rise in granulocytes.._.._.~-No URI; no rise in granulocytes___-~- - Group I and 56 percent of the individuals in Group II developed URI. Seventy percent of the affected individuals developed symptoms between the 27th and 32nd post-exposure days, 27 20 16 19 severity of respiratory infections. The incidence and severity of respiratory infection in Group IV,which had received only slight radia- and the others developed symptomsin the subsequent 2 weeks. OF INDI- | Fifty-seven percent of the affected individuals were observed to have an tion, was the sameas that in Group I and II. upward trend in their leukocyte counts, the in- The appearance of URI,therefore, did not appear to be related to the dose of radiation or to changes in leukocyte level. crease being due primarily to granulocytes. Since an increase in the mean granulocyte count of the entire population occurred about the 29th postexposure day, it seemed pertinent to determine whether in individual instances 2.5 the increase was related to the presence of respiratory infection. The relationship between the observed leukocyte increase and the presence or absence of upper respiratory symptoms in Groups I and Comparison of Diseases Seen in GroupsI and II With Those in Group IV Tue Diseases THat were seen during the period of observation of Group I and II, which were exposed to the highest doses of radiation, are listed in Table 2.3. None of the diseases appeared tobe related to theeffects of irradiation, IT is shown in Table 2.2. Seven of the 27 indi- viduals that developed both URI and a leukocyte increase developed the leukocyte increase 3 or more days before symptoms of URI appeared. It is also of interest that the medical personnel involved in the care and study of the radiated individuals had an equal incidence and either directly or as a result of hematologic dis- turbances. For comparison, the diseases that were seen during the period of observation of Group IV, which received the lowest dose of . Table 2.3—~Diseases That Were Observed in Groups I and II Drmeasze | NUMBER | or [not | VIDUALS ( * Dismase | Nuwnge or [NOI | VIDUALS | Furunele____..-...-2-2---2-2-2 2 +2 -Gum Abscess. -.... 2-22-22. 2---------- 2 l Mitteischmerz_......--..---..-2.----.-Generalized urticaria..........-..----.-Erythema multiforme_._........-------- | it 1 1 Cholecystitis...-._. 2-2-2 222.22.22---2-Tinea. -._--.- 2-22-22 e eee Migraine headache............--_-...--- | 1 t L 1 | Bronchitis. ....-..---------------------- fo Aphthous ulcer of tongue_._-----.-~-----1 Spondylolisthesis._.....--.-------------Impetigo.._...-.---------------- 2-2 --- Tooth extractions. .....----------------Gastroenteritis. _._....-----------------Upper respiratory infections. ___....------ Follicular tonaillitis. .....-.-.---.-------- I 5 2 10 47 l