thee 5
Table 30
Te
Distribuuon of Haptoglobin Types in Micronesians From Rongelap Acoil
Type l-1
.
Group
?
All Rongelap
Selected* Rongelap
No. in
Observed
group)
»
No.
176
124
33.5
33.1
39
41
Type 2-2
Expected,
Observed
No.
™~
No.
39
~
18.2
15.3
32
19
Expected,
Type 2-1
:
Observed
No.
“2
No.
3135
-
472
500
83
52
Expected,
0 and rare tvpes,
Observed
No.
"
No,
85.5
-
il
1.6
2
2
*Famuily groups include oniy one child (see text).
were visible; two of these were very faint 2-2’s, but
the fastest-moving haptoglobin band was not seen
in them.
one another, and, if superimposed, exhibit bi-
Considerable caution must be exercised in extrapolating to an entire population the gene frequencies obtained from a small sample. This is
unexposed groups shows almost identical mean
BAIB excretion values for che two (exposed, 2.07 =
modality with the antimode tn the neighborhood »
rd
particularly true when studying societies made up
of small isolated or semi-isolated groups which
“er
compartmentalize the breeding community. Thus,
the Rongelapese appearto havea fairly highfre-
quency of type 1-1, consistent with the general
al
5 25)
(though not exclusive) rule that in Europe-Africa
and America the frequencyof type 1~1 is higher in
populations living near the equator than in those
du
QW
z
had
a 20r
7
2
i
z
remote from it.
It is clear from the Micronesian studies that, at
least in some cases, an individual may have no
haptoglobin at one time, but have sufficient hapto-
AMERICAN WHITES
N=300
tad
2
Oo
Lod
x
Lie
globin to permit typing at anothertime. (In this
case, the interval was 2 years.) Examination of the
ahaptoglobinemic individuals gave no significant
findings. With =% of the Rongelap population
sampled,all the ahaptoglobinemicindividuals fell
into one family grouping. This did not help to
elucidate the genetic pattern, except to makeit
lO
4
Lo
cretion for the Rongelapese and that of a New
York City white population for comparison. The
two distributions are essentially complementary to
1189992
2S
FREQUENCY (PERCENT)
Oneof the sibs of an ahaptoglobinemic was a types
B-Amino-iso-butyric Acid (BAIB) Levels. Figure
. 46 shows the frequency distribution of BAIB ex-
(20)
MARSHALL ISLANDERS (RONGELAP}
appear unlikely that the Hp’allele, if such exists,
is not at the same locus as the Hp’ and Hp*alleles.
2-1.
615)
15
2.0
2.5
3.0
mg BAIB
mg CREATININE
Figure 46. Frequency distributionsof urinary excretion
rates of 8-amino-iso-butyric acid of Marshall Islanders
(Rongelap) and U.S. whites.
Meee
te tend
tween high and low excretors, it is estimated that
nearly 90% of the Rongelapese are high excretors.
A breakdown of this population into exposed and
OT
of 1.75. With this point used as the division be-
The Micronesian sera studied were all transferrin type CC, which is the common European
type.