2ZoocUse of Iodine 131
purine a rediocutograpk of the chromatocram by placing the paper egainst
phetoeraphic Film tn a dark room will show the positions of the radioective compounés even though the actual amounts present would have to be
inereaseé a thousané or even a millionfold in order to be seen or weighed
or studied by ordinary chemical techniques.
Ss
tied
By conventional chemical studies, even with radioiodine, the iodine
ng sutstances of the thyroid heave teer. separated into only three
Inorganic fodide (such as that in todized table salt).
2
A frection having solubility characteristics similar to those of
Sioéceyresine
2.
(bre result of sfding two lodine atoms to a molecule to
A fraction with solubility like that ov thyrozine, the substance
sileved to be either the thyycti? hormone itself or sn essential part of
that hormone.
(Thyroxide is nede up of e dilodotyrosine molecule combined
ining portion of another diiodetyrosine molecule, end
When the thyroids of rats injected with radioiodine
were studied by
“chromautograms", 1.6. recdioautozraphs of chrometograme, as described
above, radioactive spc: were found at the positions taken by pure inorganic Lodide, dilodotvyrosine and thyroxine, but in addition there were a
fes of unexpectcd redioactive compounds.
The most intensely
radioactive of these unoxnectad spots hes seen tentatively identified as
monolagetyrosine since 15 coineides exactly in position end shape with
the cclored spot Obtained when ea relatively lerge amount
(i.e. a few
Be