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LARSEN et al.
IAEA SM 224/607
‘The present studies suggest that there ts u signilicant risk
of development
of impaired thyroid function many years following
estimated thyroid doses of
less than SU0 rads from the muxture of radiomdmes present
in fall-out fiom
nhucteat detonations in the Rongelap and Ailingnae
groups, the effect has
apparently aot been signsicantly severe as to result in
clunmcally evalent hy po(hyroidisin, but by currently accepted criteria there is
evidence of Mu paired
Uryroul reserve in these subjects. I left untreated,
if would be expected that
thyroid function would continue to decrease in such subjects
to the pout of
fo]
or Aol this preliminary evidence of thyroid dysfunction cat be
confirmed.
In suminary, these data indicate Uhat ain addition
to thycotd nodularily, a
welb recognized mantlesda lion of exposure of the
thyroid to radivactive todd
or exteenal radiation, biochemical evidence of thyroid
dystunction can appear
as long ds 25 years aller thyroid doses as low as 35U
sads.
HEMPLIMANN, Ll, HALL, Wi, FUILLIPS, M, COOPER, RA, AMES,WR,
Neoplasins a pedouns Wealed WHR X bays i intaney, fourth survey un 20 years,
J. Nail Cancers bast SS CEU 7S) S1Y
—
|?
OBLENS J. RALL LE | CONARD, KA, Late eitects of radaoucdive wodane in fallout,
Combined Clinical Stadl Conference at the National Lustiiudes of dealth, Ann. ditera,
Med 66(196/) £214.
[5]
LARSEN, PR, “Radioimmunoassay of thyroxiac, (rodothyronme, and thyrotropin
io human serge”, Mangal ol Cliucal diumunghoygy CROSL, NK, ERELDMAN, H, ds),
Amencan Society for Microbiology, Washington (1976) 222.
clinical hypothyroidism. The data ia Table VI also indicate
that the fiequeacy
ol an elevated serum TSH, the earliest biochenic
al evidence Of impaired dhyrou
funclion, is also significantly more conmmon in the
exposed Rongelap population
flan the control-unexpused group. There are
several viher ex pused Rongelap
tadividuals in whom resulis of basal TSH and at
least one TRH test have suggested
the possibility thal they may alo have evidence
of Impaired thyroid function
Vhese indivutuals ate curently underguimg repeated
iesting to determine whethes
1b3
{9}
SABERILM , UIIGER, RD, Adginchiaiien of thyrulrupin feaspunses Lo tbyrotropan
redeastag hormone bodlo wag sinall decreases in scrum thycotid hormone woucenliations,
$ Chia Lindon) Mejat 4001979) 445
|
SAWIN, CT., WE RSHMAN, 3M, Phe TSlt response fo thyroliopin releasing hurting
(ERA) sh young adult mca. tidia individual variation and relation ta basal seruan PSa
and thyroid horuones, ) Clin baducrimol Metab 42(19/6) 89
[ha]
BIGOS, S.T | RIDGWAY, EC, KOURLDIES, LA, MALOOF, Bo The spec tium of
pHuilary alterations with aiid aiid scweee thysukd apalment., J Chia baducunol
Metab (in preas)
{!2)
MAXON, HER , VHOMAS, SR SAENGER, EL, BUNCHERK, CR
KEKREIAKLS, IG,
fuming bradisthon and the mduction of clinically sigatlivant discase in the human
thyrutd ghand , Am } Med G3¢1977) Yo?
[)3) BECKER, DV, MC CONAHLY, WM | DOBYNS, BM | “The results of the dhyroloxicosis
themapy lollowup study”, Further Advances in Thyroid Research F (PELLINGER, K ,
HOFER, Ro, Eds}, Gistel G ct Cie, Vieuna (19/1) 603.
ji4) UNTIED SIATES NUCLEAR REGULATORY COMMISSION, Reactor Salety Study,
An Asscosmicat of Accident Risks in US. Commercial Nuckiur Power Phanis, Appendia Vi,
ACKNOWLEDGEMENTS
Calulations of Kegetor Accident Consequences, Rep. WASH 400, NUR EG: 75/014,
US. Nuclear Regulatory Comision, Washington (1975), Protection of dhe thyroid
Plas work was supported mn purl by the Departinent
of Lneagy.
Fd
.
.
.
PR
Larsenus
an
Mvesligutor, Howard Hughes Medical Institute.
gland an tie event of scleuaca ul rudtotodine, Kecummnicuidlations of the National
Counul on Kadialion Protection and Meayurcments, NCRP Rep No 55, Washingion
We aie gratedut tu 8.1) Bigos for allowing Us to review
Ret. {11} belure ats
(iv7))
publication.
'
DISCUSSION
REFERENCES
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[4
[>
CONARD, 8 A. ct al , “Sananaly ot thyraid
findiigs in Matotallese 22 years atter
expusure fu fradiuactive fallow”, Radial ion-Associated
Thyroid Carmona GE GROOT
J bd}, Grune & Stratton, New York (L977)
24)
CONARD, KA.,elal, A Twenty Your teview
of Medical Findings in a Matshallese
Population accidentally exposed tu Kadiuacti
ve fallout, Rep BNL 50424, Brookhaven
Nattonal Labusatuzy, Upton, New York (Sep #975)
CONARD, KA. Acute snyelugenuus leuke
nite following fallGud sadtazwu exposure,
J Am Med. Assoc 232(1975) 1356.
SUIOW, W W.CONARD, R.A, “The effects
ut falivut tadiation on Marshallese
chauldica”™, Kadtution Biology of the Petal
and Juvenile Mammal (Proc. 9th Aun
Ihanturd Bighogy Syinp Kiclland, 1909} (hYo%)
ool
KRALL JE CONAKD
M DELPLA:
cnough Co suppeess the hurional actividy of the thy tot gland of two cluldsen
contaimotted when they were one year old. In fact, to obtatn such a iesull,
doctors have to administer a dose of Ff giving af least (HUQ 000 pad
Hoos tue
(hot this applies tu adults, bud all the same the dose duiference appeats considerable,
KR A. CONARD. ‘There are uncertamies an the Uhysotd dose estimates tn
Use Mursliallese, particuhuby adhe chiddien, Pagiee it would sccm likely Ghat
the (wo boys who developed myxocdema received higher doses Cha Chose
vatiiaied tu produce alropliy of He thyroid gland,
KO SHIMAQGRA
RA Ph levations Gt die seraa Ptaloue
bound vote level aa
Wobalatents of (he Absistiall Isivads, Aaa J Med
$0 C1900} BAS
2 wonder what rehance can be placed in Ure doses you
icpaurt, becatise | do mot beireve that LQOU rads, or even 1500, would have been
Phe novmnal hunian thyrutd js iadioresisdant as bar as
layrotd fumettom is comecimed, patients wile head and neck Lunouts leaked by
even.