106 : LARSEN ec: al. [AEA SM-224/607 TAHA aE PRIOR EVIDENCE OF FHYROLD HYPORUNCTION AND CALCULATED LHYROLD EXPOSURE Subject Desuiipiion 1. Two subjects with bank hypothyromism 10 yeals ables exposure 2. dave subjects widh by pothyroidoan of desicased thyroid reserve pre-uperatively 3 hoittion which are descabed below, Occastunally, (his tastraction was not followed. dlowever, Uae matinee of the tests pectormed was such Ghat this cuuunistunce would cesuit ia an underestimation (radher than ae overestimation) uf the frequency of abnormalities in Ehytond: barction Tityiuid Plasma was sepataled by allowing the aed cells do sediment aad was irdzen Wentitialion esllinsted dose number (ads) willie cight bouts ulter obfaming fle specumen 3 Lisa 4 hisu ‘Lhe nonmaltange for serum PSP in one labGiatery bb from <0 05 tod plifial Serum Playroid Stuayulading Hounone CPSED and thyroxime (14) were micusuied us previgusly described [8] im the United States population Gmean 2 0 wf) 2 BIU bisu 20 Bru 1150 33 Blu LISO 42 B10 1150 65 siu 1150 Dhyrotropin Releasing ltotmone CL RH) stimulation tests were perlotimed by aftsion of 500 py of TRO B inttavenously, plasma sumiples were oblamed af O and at 20 tunules afte: the tnfusion PSU) stuulation tests were pecormed By administration of ten units of boyUSE tatiaiusculaily with plasma obltaned for), dete umnutions belode jection and 24 hours later, Phe norinal ange lor serum Ty concentoa tions 65) V0 pe/dd Estuniion of the fice traction of T, was obtamed by a Py charcoal uptake metal developed in oar laboratory (1 0G Index) Twenty dive wl ol plusina are incubated in biabot glycine avetude butler, pila 6, comlaumnig Ihice subjects with unpaired thyroid tun tion lolluwing sublotal thyroidectomy 1G? 17 a10 i150 M07 21 Blo 4450 to sediment the charcoai “Phe taction of the dutal if, bouwud to charcoal Dextian couled charcoal is added af 4°C wath subsequent con tifugalion 6Y SIU J150 is detuned and this result is normalized to the tesolls of simullancously assayed quality comlrol samples comlaining Hetil quantities OL by and thyrexie -bindiag globulin (1) BG) Uhe norual range for the testis O85 1 10 The TBG Indes iicteases parallel to the ree (hacthon of the serum by and i, and is dheteduse elevated in hyper Uiyroidian or PRG deliicney (ABLE LD RESULTS OF TSE STIMULATFLON ‘FES ES IN EXPOSED KONGELAP SUBJECTS AND CONTROLS Mean 4 SD Mean serum TP, Mean scrum ‘ly Priar io PSiiq)g U PM) mnerement 24 h aller PSit Controls oUt tL? Hlta3 baposed Rongelapese ooL17 24th2 (un - 20) TSE stimulation fests (pag (1) MLVUWODS Studies were perlommed duaing (he aontal or sean anial visits of the Bivoklaven medical team tu the Marshall Islands. Subjects were ustructed to dbo ontinue thyroid medication tor two months belure Uhe studies of thyrond Vo dictermine whether or nut there was mnpaiics Ehiytaid reserve: see tbe capused subsceds, TSEP stimulation tests wore caiiicd Gul usiig ad micreause tn ce ne ee (uae fd RESULTS serum dy as the response endpoint fa normal subjects an the Gated States of Anieiiva, (he pean daecreuicnt a plasma Py waa 47 2b g/dl Giiean t SD) in 13 stibjects folowing myection of WOU of PSHE ta balde Tare shown data tur Mie Maasliall bsbiinks population dhe control subjects who hat net been exposcd lo idition were given PSH, and the mean incecmieatin Dy was 4.2 £0 3 (SD) not stetiotically dilbert thom the results ithe naled States populution However, mb 24 caposed Kougelap salycets, a mcan mcieiment of ouly 24 td 2 psd wos obbatcd, which wos simiticundly bess Gp sO GOP) than i lie Comdial subyeccts