peo
re
110
1AEA-SM-224/607
LARSEN ¢1 al.
707
lil
and the PSE response to TRE was abso significandly mecrcased, midicating the
presence of tmpalied thyroid Cunection.
Chasacteristics of Marshallese with biochemical evidence of Uryroid dystunction
40
1
bn Table Vil are presented the results of other studies mi the lous indiveidials
PL aSML
TSH wus
with biochemical evidence of inpuired thyroid fuaction. Al present, these are
the only gidividuals who have fulliiled the crtena described in table V, though
30 7
several otlier subycets have shown al feast one abnormal tinding but have aod
had the required number of tests lo meet the established criteria
Vhhe age al
vaposure Varied trom 16 to 38 years and the estimated thyroid dose was thought
ti three Of four bo be less than 400 rads. Serum Fy concentrations ta all tour
|
subjects wie inthe low notimal range when Comsidercd in the light of (hear
estimated serum Viytoxine- Banding Globulin CEBG)}
Subjects 74 and 71 have
approximately nomad serum TRG concentrations, whereas subjects 78 and 4
Jpparently have a modestly clevated serum TRG.
ba the kasd columuiol Latie VIE
are shown results of Uie TSH stimulation tests of these subjects performed in
1974
FIG)
da all three, the scrum Ty response to USE was inpaired, suggesting
decreased thyroid ivserve
Basal pleasing TSH and TRH-stunuduted TSH
tn euthyroul Marshallese and in four exposed subjects
ol
with bier hemuwal evidence of unpaired thyroid
(NORMAL.
HANGE
BASAL
function.
DISCUSSION
Plasma was ebtuined 20 ini uffer iitfusiwn
of S00 py TRH
AFTER
TAH
The upper lteits of the nurmal senge
are indicated by the shaded bars.
An association of thyfuid nodulanity and cancer with poror radiation of the
thyroid gland, particuludy in younger patients, ts wedl recognized aud the
dasuclulion hus recently been reviewed FEL)
TABLE VIL
CHARACTERISTICS OF MARSHALLESE WITH BIOCIIEMICAL
EVIDENCE OF THYROID DYSFUNCTION
Subject
Age af
ExXpusure
Bstumated
5
thyroid dose
(rads)
Normal valucs
t
cums
(g/dl)
5
10.2
of hy pothyruidion within one year and a 13% probalality in 3 years [13].
There are few dala avatlable in the titerature relative to the possibility of
(pagfda)
1.10
16
Lhe
luwest dosage considered in previous studies of (lis type has been approximately
3400 rads estimated dose to the Hayroid which was associated wath a 6% probability
244hp Tse
units
0.85
with thytoid dysfunction is assocmicd wilh hypothyronlisay in a signidicau
fraction of the patietits (as high as 50%) al the higher dosage levels [E22]
Va laciement
TaGl
dn addition, do has been recognized
that radiation tu the thyioid delivered in the Course of treatment of pulients
hypothyroiisi following (dosages of dess Chan 2500 ads. Prelimanary results
of Hamilton and Lhompkins indicated that eight of 443 subjects (1.8%) subse-
64
quently became ly pothyroid after diagnostic '2'P tests at less than 16 years [13]
74
ty
335
5.8
0.97
Os
71
28
345
52
0.98
N17
7a
3?
335
6.1
4
0.82
Us
34
With an estuaated thyloid absorbed dose of 30 rads developed hy pothy routs,
but tice of 140 subjects receiving J) to 8G rads estimated thyroid dose had this
345
14
0.79
uy
condition [14]. OF PST subsects with an estimated dose range of 81
*
810
A sumunary of these preliminary data has been presented
None of 146 subjects
,
|
1900 rads,
five hypothyroid patients were found with an iickence of hypothyr oidisin of
O 25% yearly
Not tested
:
.
i
t