AMANO FRUUCL TLE OF ALIUNLPOLEES TE OY ooDY Submitted: VESTIGATION: A Study of the Physiological Function and] Histological Changes in Thyroids Irradtated wi Radioactive Iodine INVESTIGATOR: Brown M, Dobyns, M. D., Ph.D. Professor of INSTITUTION: ye” y 1, 1966 Surgery, Western Reserve Uni Western Reserve University School of Medidine at Cleveland Metropolitan General Hoap tal (former1 Cleveland City Hospital) ‘ ANNUAL REPORT - JUNE 2, 1965 to JUNE 1, 1966 407562 The work carried on under this project represents a broad physiological and morphological changes in the thyroidof man and of _ following the administration of radioactive focine (1131), 3 A very detailed report covering activities from the begimming bf the project was submitted one year ago. Radiation Effect on the Function of the Thyroid in Clinical Subje the early years of the project more time was devoted to} the physiologic effect of the radiation than to the morphologic aspects of it. Selected patients were studied in very great detail so that ° effects of 1131 therapy could ultimately be measured against : ground o¥ data on each individual patient. ical largk back-. It was hored that 3 this way, i* might be possible to find explanations for the great variation the response of different patients to this therapy. The many studies that have been done, and are being continued, on each of the selected patients were discussed in detail in the previcus reports, especially in the lengthy review submitted one year ago. The series of observations are therefqre merely listed here. -In addition to the usual thorough clinical work-up of the patient including: . hematolegic studies, estimation of the character and wefight of the thyroid, systematic recording of all features of ophthalmopathy ‘the PBI, the uptake of 1131 and the clinical judgment of the severity of the hype thyroidiem, a series of special observations were mide on these selactec patients. It is these special studies that are supported by this grant. They include the following: DThe uptake of the treatment dose by the thyroid and repeated (almost daily observations thereafter to determine the pattern of disappearance of ‘the I from the thyroid over a period bf up to three weeks. 2) Sampling of the total radioactivity per milliliter of blood over the same period of time. 3) Serial quantitative chromatogramaj to show the amounts of varicus fodinated compounds in the hlood (5 to 8 samples per petient) to reflect the changing pattern of these comoounds following the administration of the treatrent dose. 4%) Similar observations on the urine with attention to the daily total loss of radioactivity from the body. These serial observations not only initially reflect the abnormaliti#s of the disease process and variations among patients before a substanti BEST COPY AVAILABLE ™ \ ew wrwemanr fey Theres