we ee im on these children are given in Table 10. Clinically no indication of any disorder involving mineral metabolism or thyroid function was apparent. LEUKEMIA SURVEY On physical examination no evidence of lymphadenopathy, spleenomegaly, or othersignsof leu- kemia were detected. Hematological examinations showed no excessive leukocytosis or increased numbers of immature leukocytes in smears. Basophil counts on 4000 leukocytes on each individual showed no elevation of the basophil counts. Alkaline phosphatase studies* on the blood smears showedthat, although some people had lowlevels, this finding was not associated with anvotherfindings suggestive of leukemia. STUDIES OF AGING CRITERIA The results of aging criteria studies are plotted in Figures 16 to 32. Individual readings are plotted (circles), and also mean values for each 5year group combining exposed and unexposed people (squares). The trend of each criterion with increasing age is represented bya line of approximate best fit by eye except in the case of handgrip data for males and females (Figures 30 and 31), which were foundto fit the following formulas:** Y¥=60—0.405A (males); Y=42—0.405A (females) The values of the criteria either increase or de- to previous exposure. This type of pigmentation was observed less extensively in the unexposed comparison population. In 10 cases comparison of pictures of these areas taken soon after the appearance of lesions in 1954 and then more recently showed that the maculae had developed subsequentto the lesions. (See Figure 33.) Biopsies were not taken this year but may be considered at a later date for study of the histological appearance DENTAL SURVEY A total of 59 school children were examined and treated for caries prevention. Ofthese, 29 required *We are indebted to Dr. WiC), Moloney and Miss Lila Fliegelman of Boston City Hospital for carrying out the alkaline phosphatase analvsis of bload smears. treatment such as fillings, extractions, and pro- **We are grateful to Dr. R. Hinchcliffe of the State University at, Residual skin changes from beta burnssustained in 1954 were observed with certainty in about 10 individuals. Most of these residua consisted of mild changes such as varying degrees of pigmentalteration giving a mottled or blotchy appearance, sometimes accompanied byhyperkeratosis (increased rugosity) of the skin. Some showed more pronounced changes than others, such as atrophy andscarring. Noneofthe residuallesions showed any gross tendency to changesassociated with the developmentof chronic radiation dermatitis, nor was there any evidence of malignant changein anyofthe lesions. As noted last year, in a few cases previously affected areas showed some dark pigmented maculae (lentigo-like). A fewappeared as raised moles. It is uncertain whether these lesions are of casual developmentorrelated crease generally with increasing age. Sincethe re- of lowa for making this observation, co RESIDUAL BETA BURNS of the lesions. In Table 11 are listed descriptions of the residual!lesions. where 2 = handgrip in kilograms and A = age. C4 sults’are similar to those in last year’s report,’ which were given in considerable detail, a lengthy discussion of the various changes will not be included here. Again, little or no difference was apparent between the exposed and comparison groups of the sameage, and therefore no discernible effect of radiation on the aging process was noted. Further statistical analysis is needed for more adequate evaluation of the various parameters and better estimates of biological age scores for individuals. It is planned to repeat studies of aging criteria every 2 to 3 years. , phylaxis. In the total group 17 showed some evidence of enamel hypoplasia and indication of possible carious lesions in the near future. A een ere: am + ee pared to those of their sibs are shown in Table8. Medianheight for controls at the chronological age of 8 years was 122.5 cm for males and 120.0 for females. The skeletal ages for these same children as comparedto those of chronological age peers are shownin Table 9. Subjects +3 and =5 continued to show markedretardation in physical and skeletal growth. Subject +65 has shown a spurt in statural growth but continued to lack somewhatin skeletal maturation. Calcium, phosphorus, and protein boundiodine determinations nets cinmemaccemee FD ate 22