- 20 Comments: The author's reference (40) is to the paper by Benditt and Benditt (1973), whose statement in this matter is as follows: “Chemical, mechanical, and nutritional manipulations have been used in animals in an effort to reproduce lesions like those of atherosclerosis in man: none of these experimental lesions yields wholly satisfactory copies of lesions of the human disease. _ The next sentence in the Benditt and Benditt paper is as follows: * Spontaneous atherosclerosis occurs in chickens and, as we have found, produces lesions that strikingly resemble those of men. The fact that certain types of experimental manipulation may have failed so far to reproduce wholly satisfactory copies of lesions of the human discése does not mean that some of those lesions which have been “produced are wholly irrelevant or that radiation is the only egent that would be perfectly successful. Experimental manipulation with radiation has not succeeded in meeting this requirement either, Since other animals are not wholly like humans it has been difficult, but it is not necessarily impossible for the future, to produce good copies of the human disease by experimental manipulation of factors other than radiation. Perhaps investigation of the spontaneous lesions in chickens would provide valuable clues, Page’11, lines 10-12 - "However atherosclerotic plaques have been directly induced in human arteries by intensive irradiation with x-rays and radium au Comments: The reference (45) is to a paper by Sheehan (1944) on what Sheehan calls an uncommon or at least rarely described lesion, i.e., foam cell plaque, observed in the intima of irradiated small arteries (100 to 500