- 14 Page 10, lines 22-26 - "Let us review the mounting evidence which suggests that inhaled insoluble alpha emitting particles may be the agent of atherosclerosis and thus give rise to an increased risk of death by early coronaries and strokes, Atherosclerosis is reported to be present in every instance of partial or complete arterial occlusion and every case of coronary thrombosis(39) ," Reference 39 is identified as a 1940 paper in The American Heart Journal pertaining to arteriosclerosis of the coronary arteries and the mechanism of their occlusion. The journal volume number was not provided in the reference list, and we were unable to find the paper by means of the year (1940) indicated in the reference listing given. To date we have not yet located this paper. Page 11, lines 1-3 - "Recently Benditt has shown 640) that the human atherosclerotic plaque is a monoclonal proliferation of a mutated cell of the artery wali, and thus an arterial tumor." Comments: Clarification of this matter requires explanation of what the paper of reference (40) by Benditt and Benditt (1973) actually reports and ' shows. . First, it should be pointed out that early-in embryonic development of mammalian females there is random inactivation of one or the other of the two x-chromosomes in various cells. Thus, the female becomes a mosaic of two cell types, each type having one or the other of the pair of x~chromosomes active with respect to x-linked glucose-46-phosphate dehydrogenase isoenzymes. The two cell populations reproduce true to ‘type in this respect throughout somatic growth, it is thought. Benditt and Benditt (1973) referred to Linder and Fartler as having examined the nature of the cell population in benign uterine smooth muscle