~ 13 Page 10, lines 12-18 - "It has long been known that those tissues in which there is more active cell division suffer the earliest and most seve severe radiation damage effects, and that this includes the blood forming cells in lymphatic glands and in bone marrow. , . Such effects include the destruction of rapidly multiplying cells that produce the blood platelets which assist in the control of blood clotting. Similarly the population of leucocytes is reduced with a corresponding reduction in resistance to disease." Comments: These sentences apply primarily to the acute radiation effects seen after high exposure levels. Their relevance to the effects of alpha emitting radionuclides is not clear, Page 10, lines 18-21 - "These effects plus the accompanying chromosome structural changes can give rise to the earlier incidence not only of cancers, but bbs ybote pattern of diseases of the cardiovascular and renal systems ? ." Comments: The author, referring to the fact that radiation can damage or destroy cells that produce blood platelets and leukocytes, states that, "These effects plus the accompanying chromosome structural changes can give rise to the earlier incidence not only of cancers, but the whole pattern of diseases of the cardiovascular and renal systems‘? +38) 1 This statement, the manner in which it is made, and the sweeping implications of it are misleading, non-sequitus and unaccompanied by adequate meaningful explanation of foundation. It attempts to faction- alize mechanistic connections- which are so remote and speculative, and neglectful of known aspects of the mechanisms, as to practically meaningless. The references [37 (a publication appearing in 1938) and 38] do not provide substantive support for the sweeping mechanistic aspects of the statement.