58-21-1994 12:14
5162825311
BNL-MED. DEPT.
P. 008
=f
(7 - 9 days).
The platelet count may reach very low levels after tYo weeks,
Ex
Thgs group repre
ternal evidence of bleeding may oceur vithin two to four weeks.
sents the lethal dese range in the classical pharmacologic senae,
this group
the symptom free period (the latent peried) lasts from one to three
eeks with
little clinical evidence of injuries other than slight fatigue.
he termination
At
of the latent period, the patient nay develop purpura,* epilation o
1 and cutaneous
lesions, infections of wourds or burns, diarri:ea or melena**.
rtality will be
simnificant,
The
With therapy the survival time can be expected to be
olonged and if
siffielent time is provided for bone marrow regeneration the surviva | rate will te
inereased,
In group 1 (Survivel impossible} and ercup 2 (Survival possible }
nicture is not as well documented as in ereup 3 (Survival probable),
the bleod
There are
geod clinical reasons to believe that in the lethal range the cromaferts depressions
vill be murked and below 1,000 per ran? during the second week,
in Japan confirm this contention.
Obse: i'yet'ons made
Mowever in the sublethal range it
takes much
longer for the granulocyte and platelet count of man to reach minima] values, as
compared to other mammals,
Despite the chaotic conditions that exis ed in Hiroshina
the data of Kikuchi and Wakisaka (11) shows that there was a more ra
decrease in groups 1 (Survival improbable) and group 2 (Survival pos
group 3 {Survival probable).
Before going on to group 3 survival
pr
refrain from a comment on therapy.
Much has been learned from the experimental therapy of radiatio
animals.
injury in
It has been conclusively st.own thet protection can be affor ed by the
transplantation of bone marrow from one strain of animal to another,
The protection
afforded by transplantation of genetically specific material, that is
‘from one
member of the same strain to an irradiated member of the same strain, is very good
and long laating.
If the material for transplantation has its source in another
strain of mouse, the protection is less marked and not as long lasting.
*
Bleeding into skin
** Black stools from digested blocd
If the