Bete @esene Peeany . r- ’ . be . [. i Po f= . COLOR PLATES t F Phoitea S.ER through 3.2) show desronm ad 22 daye post exposure (Plates W108 through 3.20, be . i Case 26: Plate 4.21, Case 3). mm! Plate 0K (Xbo0, HABE) Epidernis: fatensive: tismosepidermial damiupe with leas mvotved zones on either side. Loose banmoiiition of stratuin corrmeun, obaence of stratum graniulasum. Porakeriutinivation with exloludion of pigment containing cells. Disorganization of the maipighian layer. Dermis: Mild edemaal pars papilliicis with andistinet capillary loops. Moderately pronounced perivascular cellular infiltrate (lymphocytes and movonuciear phagocytes), : incsuperfiedal corm with mald felunpgrectisis, Plate 3.10 (X100, H&E) Eptdermis: Arcades of minimal damage occur in relation lo excretory ducts of sweat plaunds. St ratium granulosum of good width and shows scant alteration, Underome praetees lying stratum malpighit shows marked decrease in pyrment, In the deeper portion of the overlying, loosely laminated strutum corneum moderate amounts of pigment, however, are present. One narrow arcade of more severe transepidermal dumage shows alteration of the stratum granulosum with intercetular edima, pyknosis, swollen nuclei, and pigment scattered through- out. The lather 15 especially dense in the contiguous purakeratotic material. Dermis: A mod- : erate cellular infiltrate, chiefly perivascular, is most pronounced in the superficial pars reticularis where there is a mild telangieetasis. es Plate 3.20 (X400, H&E) (Case #26) ‘Transepidermal damage with disorganization of the malpighian laver. Stratum pranulosum absent. Malpighian and basil javer only two to three cells thick with: xfoliitien of pagment outward toward parakeratinized zone adjacent to striatum corneum. ygment taden chromatophores and histiocvics in pars papillaris of corium. Latter edematous and cifibtraded by moderate numbers of lymphocytes, mononuclear phagocytes and scattered prezmented leukocytes. Capillary laops indistinet, r a * - , . ° - Plate a.2b (OCT00, WME) (Case #63) ‘Pransepidermal dimage with disorganization of the malpiphian dayoer. Slight purakeratosis. Migration or exfoliation outward of pigment. Loose lamination of stratum corneum. Payment tuden chromatophores and histiocytes in superficial pars papillaris of corium, Marked celluher infiltration of purs papillaris. Stight telanpiectasis of superficial pirs reticularis, : oe ese esetene eeaseas . * veetes e eove eaae . , ie t eese *