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stage in severe cases, which showed remaining
and proliferation of plasma cells and reticulum
cells. With the beginning of recovery, aplastic
marrow changed to hypoplastic and then turned
into a type of maturation arrest. Recovery was
not complete even after one year.
In the cases
not so severe as these, the bone marrow was
not aplastic but hypoplastic or a type of maturation arrest even at the critical stage.
20
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RBC
Fig. 4.
Cumulative Distribution Curves (RBC)
Platelets
Platelets counts showed increasing depression,
reaching minimum at the 4th-7th weeks. The
recovery began during the following several
weeks,
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critical stage
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The cumulative percentage curve still
displaced to the left of normal curve after one
year.
The results of other tests related to haemorrhage showed depression at the early stage in
general and recovered by the 10th week.
Bone marrow
The bone marrow was aplastic at the critical
Morphological abnormalities
Several morphological abnormalities, e.g. abnormal granules in lymphocytes or neutrophils,
vacuoles in various leucocytes and megakaryocytes, giant nuclei and hyper-segmentation of
neutrophils, binucleated lymphocytes, abnormal
mitosis of erythroblasts, etc. were observed for .
about one year, especially at the critical and
the recovering stages.
Erythrocyte sedimentation rate was accelerated in
the early stage in some cases.
4. Spermatopoiesis
The examinations of spermatopoiesis were per-
formed on 18 patients several times.
Number of spermatozoa decreased about 2
months after the initial
exposure,
and azoo-