.,”.
1726-2001
Range
87-101
3174-9078
160-458
From the above the minimum estimate of cancer risk would be given by a
risk coefficient of 87/106 person rem and the maximum by 458/106 person
rem.
Thus, these two risk coefficients were used to define a range of
estimated
2.
cancer deaths.
Genetic Effects (from Page 1 & 2 BEIR-1)
a.
Based on specific defects 5 rem/30 year reproductive
generation would cause in the first generation
dominant diseases and defects per year (3.6
at equilibrium.
million births/year)
The 1800 cases represent
or 5 times this amount at equilibrium.
an increase of 0.05% incidence
100-1800 cases of
per year first generation
and 0.25%
In addition there would be a few chromosomal
defects
and recessive diseases and a few congenial, defects due to a single
gene defect and chromosome aberrations.
The total incidence at equilibrium
is 1100 to 27,000/year.
These
at equilibrium, the maximum would be 0.75% or 0.15% in the first
generation.
These are equivalent to 0.15% per rem at equilibrium
and 0.03%/rem
in the first generation.
b.
Based on overall ill health.
Overall
of ill health is proportional to the mutation
ill health:
~% - 50%
rate using 20% and
doubling dose of 20 rem, 5 rem per generation would eventually
lead
to a 5% increase in ill health.
Thus the rate of overall ill health is 1%/rem at equilibrium
or
0.2%/rem in first generation
For estimating the potential genetic derived health defects in the
Bikini population it was dec ded to use a risk coefficient
per rem in the first generat on recognizing
very conservative.
of 0.2%
that it was probably