NATIONAL INSTITUTES OF HEALTH CLINICAL STAFF
Several points of interest are revealed by
these data. The two subjects with severe
growth retardation (Cases 3 and 5) had very
low thyroxine iodine levels, little or no
accumulation of 18*I-by the thyroid, and
very high levels of TSH in blood. The
TABLE 9.
Case
Sex
latter finding indicates that the growth retardation was due to primary thyroid failure and not to pituitary failure, which was
suspected before the appearance of clear-cut
thyroid findings. Several of the patients
who had had partial thyroidectomy (Cases
Thyroid Studies in Subjects with Thyroid Abnormality*
Thyroid
Abnormality
Age
3
M
Atrophy
vr
13
5
M
Atrophy
13
17
F
15
21
F
69
F
2
M
Nodular
goiter
Nodular
goiter
Nodular
goiter
’ Nodular
20
M
72
F
Nodular
goiter
Nodular
42
F
61
F
54
M
19
M
36
M
33
F
65
F
59
F
40
M
64
F
” goiter
goiter
Taternal Medicis
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Solitary
nodule
Solitary
nodule
Carcinoma
Year
Tested
Neck ?##J Each 4 Hrf
PreTSH
PostTSH
PBI
T,lI
13
1965
1966
1965
1966
1964
1966§
1964
1966§
1965§
1966§
1965
6.5
(29)
(23)
ug/100 ml
1.4
0.8
3.2
1.0
1.9
0.8
3.1
1.8
6.8
18
<0.5
8.1
13
<0.5
7.1
5.7
1.7
7.9
4,2
19
1965
(31)
(31)
6.5
15
16
% of dose
Serum Iodine
1966§
5
8
18
5.2
2.6
4.2
18
1965
15
1966
(15)
(24)
5.7
4.6
20
1966
12¢ (10)
(24)
7.9
4.9
13
1965
1966
1966§
19
8.3
5.0
3.9
4.3
3.3
17
19
13
13
35
40
31
1965
1966
1965
1966
1965
1966
1965
1966
1965
1965
1966§
Serum
TSHt
mug/ml
>120
159
119
248
372
440
125
9.6
26.6
5.3
(16)
(24)
17 (9)
(14)
7|| (20)
(38)
(19)
(28)
4.1
4.2
7.0
5.9
4.9
3.1
8.2
8.6
10.3
8.6
4,9
4.3
3.8
2.1
1.9
5.3
4.8
<17
<3
<17
<17
<17
7.3
197
6.6
23.5
3.4
2.0
* TSH = thyroid-stimulating hormone, PBI = protein-bound iodine, T,I = thyroxine iodine.
} Values in parentheses are “corrected” counts obtained at Brookhaven National Laboratory (see text). The
others are not corrected for extrathyroid counts.
t¢ Assays in 1965 could not detect levels below 3 mug/ml. Seven unexposed children in the same age group had
<3 mug/ml. Assays in 1966 could not detect levels below 17 mug/ml. Three exposed children without thyroid disease
(Cases 6, 8, 32) had <17 myug/ml. Two children exposed in utero (Cases 84, 86) and two unexposed children had
<17 mug/ml.
§ After partial thyroidectomy (for Case 64, total thyroidectomy).
| While taking thyroxine.
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