¢
“
,
.
..33
is essentially a review of his analysis* ,
a
which has become
known as the "Geesaman hypothesis."
A
The Geesaman Hypothesis
Dr. Roy E. Albert and co-workers pe=formed a number of
experiments on the induction of cancer in rat skin?4736,
Albert's study of radiation-induced carcinoma in rat skin
gives some quantitative description of a high-dose carcinogenic situation.
A skin area of 24 cm? was exposed
to electron radiation with various depths of maximum penetration.
The dose response curves are reproduced in Figure l.
.In all cases the response at sufficiently high doses
(1000-
(3000 rem) was large, 1-5 tumors per rat by 80 weeks post
exposure.
It was noted by Albert that when the dose was
normaiized to a skin depth of 0.27 milimeters, the three
—
--
response curves became continuous
_—
(See Figure 2).
Since this
~.
—_
33/
Geesaman, D.P., UCRL-50387 Addendum, Op.
cit.
© -—-7~ =
34/
-Albert, R.E., F.J. Burns, and R.D. Heimbach, "The
effect of penetration depth of electron radiation on skin
tumor formation in the rat," Radiation Res. 30, 1967, pp.
35/
Albert,
R.E.,
F.J.
Burns,
and R.D.
Heimbach,
wre
515-524.
"Skin camage
and tumor formation from grid and sieve patterns of electron
and beta radiation in the rat," Radiation Res. 30, 1967, pp. 525-
36/
Albert, R.E., F.J. Burns, and R.D. Heimbach, "The
association between chronic radiation damage of the hair
follicles
and tumor
1967, pp.
590-599,
formation in the rat,"
Radiation Pes.
30,
Ml
-_
afr
sul