EFFECTS OF WHOLE BODY IRRADIATION ON MARROW
485
normalities in the erythropoietic forms was reached after 2 days; that in the
myelopoietic cells 4 days after exposure. On the 4th day, there was a distinct
dose-dependent difference in these abnormalities between the high dose
group (236-365 rads) and the low dose group (22-68 rads).
2. Some cytologic abnormalities, as seen in increased regeneratory activity
of the marrow, were found in marrow smears 3.5 years after the accident, al-
though the peripheral blood counts and mitotic indices of the marrow were
within normal range. Their significance is obscure.
3. A careful cytologic evaluation of serially aspirated marrow samples
during the first hours and days after whole body exposure proves to be an
additional important aid in the assessment of the exposed individual and may
well prove to be useful in determining the degree of injury and thus the
prognosis.
SUMMARIO IN INTERLINGUA
1, Serial studios del medulla esseva effectuate durante le prime dies in octo
homines accidentalmente exponite a un mixte irradiation neutronic gamma.
Esseva notate le occurrentia de un ver unda de anormalitates cytologic. Istos
esseva identic con le anormalitates incontrate in animales experimental inter
1 e 3 dies post le irradiation del corpore total, Illos esseva reguardate como
“mitoticamente connectite” e includeva le occurrentia de pontes chromosomal
e de fragmentos chromosomal in mitoses, In cellulas de interphase, le major
anormalitates esseva fragmentos nucleari (“karyomeros”) in le cytuplasma de
erythroblastos, de cellulas myelocytic, e de lymphocytos e le presentia de bie multinucleate cellulas e de cellulas gigante. Le culmine del anormalitates in
le formas erythropoietic esseva attingite post 2 dies e in le cellulas myelopoietic
post4 dies a partir del exposition. Le quarte die, un distincte differentia in iste
anormalitates esseva notate secundo le dose inter le gruppo a alte dosage
(236 a 365 rad) e le gruppo a basse dosage (22 a 68 rad).
2. Certe anormalitates cytologic, manifeste in un augmentate activitate
regeneratori del medulla, esseva trovate in frottis medullari 3,5 annos post le
accidente. Tamen, a ille tempore le numeration in le sanguine peripheric e
le indices mitotic in le medulla essevaintra le limites del uorma. Lesignification
de iste anormalitates remane obscur.
3. Un precise evalutation cytologic de serialmente aspirate specimens de
medulla durante le prime horas e dies post le exposition del corpore total se
revela como un importante adjuta additional in le examine de un exponite
subjecto. Il pare ben probabile que unta! evalutation va provar se utile in
determinar le grado del injuria e assi le prognose in le caso individual.
REFERENCES
1. Le Roy, G. V.: Hematology of atomic
bomb casualties. Arch. Int. Med. 86:
691-710, 1950.
2, Kikuchi, T., and Wakisaka, G.: Hematological investigation of the atomic
bombsufferers in Hiroshima and Nagasaki City. Acta scholae med. Univ.
Kyoto 30:1-33, 1952.
3. Hempelman, L. H., Lisco, H., and Hoffman, J. G.: The acute radiation syndrome: A study of nine cases and a
review of the problem. Ann. Int. Med.
36:279-510, 1952.
4. Shipman, T. L., ed.: Acute radiation