- 13 4.
Cellular changes
a.
Range of sensitivity of cells
(list most sensitive ~ gonads - to least sensitive nerve, muscle, bone)
b.
5.
Relate sensitivity of nucleus to cytoplasm
Effects on the whole organism
a,
b.
Range of survival dose on mammals (guinea pigs 200 r,
rabbits 800 r)
Compare with non-mammalian radiation (virus, for
instance, 1,000,000 r)
(1)
6.
Point out species variation and position
of man
Clinical syndrome in man (nausea and vomiting, hematopoietic
depression, epilation, bleeding, etc.)
a.
Special place of hematopoietic response to radiation
b,
Delayed effects
(1)
Reduced longevity
(a)
(2)
G.
reduction in life expectancy validity of concept at low levels
of radiation
Production of leukemia and neoplasms (tumors)
Relationships of damage mechanisms to dosages
l.
Aplastic anemia, leukemia, and cancer as a result of exposure
to radiation
a.
Doses at which observable damage occurs; relationship
of probability of damage to dose and dose rate; latent
periods; doubling doses; relationship to tissue
irradiated
:
JCAE
b.
Relative importance of cancer and leukemia under
various conditions: external source; exposure of
various critical organs to radiation from external
and internal sources: lungs, gut, thyroid, skeleton,
etc,
2