THE SHORTER-TERM BIOLOGICAL HAZARDS OF A FALLOUT FIELD In this differential equation, the a, and «4, are known constants of the exposure function. In application to experimental daia, Z is a known numerical function of the dosages, survival times and the ageing function. We therefore havea first-order linear differential equation in the unknown impulse lethality function, #(@). Now let 7 f Z(tdt=¥ a (30) A, Daily X-ray Meon daily dove * {r) (8) Wefind DEZ+ (oy +n) Z+ ana ¥ = (D+-yAgt+ mA, (31) This is solved for C, as B. Rutt njeetlone Moun after-| Camulant survival lethality 4 (days) (rAlayi-1 andintegrate term by term, remembering that f $(t)dt= C4, (4) QUANTITIVE ESTIMATION OF RADIATION INJURY AND LETHALITY TaBse 2.-CUMULANT LETHALITY VALUES FOR CARWORTH FEMALE MICK (A) EXPORED TO CONSTANT DAILY DOSE OF XRAYS FOR THE DURATION OF LIFE AND(B) INJECTED WITH Ru® V7A TAIL VRIN 103... .... LTA 425 63. 1 36.4) 21,91 16.4; 13.4) Mean Median injected afterdose survival facie) (days) Cumulant lethality + Kueyt se ee een} O 500 |... 0. 0256 1. 42 140 2. 047 . 0182 3.21 37 - 704 .0142 4.96 18 ~ 418 .0093 8 94 12 ~151 . 0056 |... ----) 22.2 eae Exposures given § days per week. . > Using Equation 16 with E(Z}«2 and A(t*) =p s * Thebiologic decay of Ru! was found by Walton [22] to be JAE} 3e- WOAHGe 10881 ‘This was used to deseribs the time-course of exposure, Ce"f* PYDZ+-(ayten)Z-+eyn¥dt (32) o .035 7 where B equals a,4,+ 0.4). We * have evaluated C, from some data obtained by the late Mr. Howard Walton [22] on the toxicity of Ru’ for CF-1 mice. Equation 32 was evaluated numerically, using the data given in Table 2. Figure 6 represents the numerical estimates of C, based on the rutheniumdata, and also an estimate of C, obtained from data on CF~1 mice given constant daily dosages. In both cases A(t) and E(1) were assumed to be given by Equations 11 and 12 respectively. The scaling factor for best adjustment of the +The assistance of Mr. Robert Schweisthal is grate- fully acknowledged. 030 / CONCLUSION 1 uc/g equivalent to 38.5 rep/day lethality was discussed briefly. The formal theory of lethality developed here was presented as an approach devised for the purpose was found to be The present status of the theoryof radiation The tissue dose received from retained Rul was estimated by Walton to be of obtaining information about. lethality, re- garded as a physiologic process. It was shown that the lethality process is polyphasic, and 1 ue/g==41.6 rep/day The estimated RBEof Ru with respect to 200 kvp X-rays istherefore RBE=0.925 7 4 015 7, O10 f— when they can be given a correct physiologic exposure pattern from the effects of a known pattern, if the patterns do not differ too greatly in form. This comparison is of some interest, validity must first be determined by experiments with such patterns. in predicting the lethal effects of an unknown because Ruhas a fairly uniform distribution in the body. However, experiments with time- dependent exposures to external radiations are ° 9 methods described here can equally well be However, the argument [23] that only fractionated exposure patterns should be used in lethality studies, in order to avoid the ‘wasted radiation” received in the last days of life, has no basis. The lethality functions exhibited above are estimates of the actual makes its properly weighted contribution to { i ! 20 40 60 60 1oo MEAN AFTER- SURVIVAL (doys) Fiaure 6.—-Cumulant lethality functions for Carworth female mice. Fractionated exposure patterns are particular cases of time-dependent exposure, to which the amount of injury present as a function of time after exposure. Hence, the injury arising from exposures received shortly before death .005 Solid line—directly determined Jrom data on survival at constant daily X-ray dosages. Dashed line—calculated from date on the survival Jollowing dosages of Ru™, by use of Equation $2. parameters, The estimation of these parameters by nondestructive methods will be possible at 140 days is perhaps somewhat high. It would appear from these results that the linear model, despite its shortcomings, is useful applied. 020 that the several species studied appear to show considerable independent variation in the amplitudes of the different phases. The construction of an adequate lethality function for manrequires knowledge of several independent The two estimates of the cumulant function also agree in shape, although the C, value from Ru! needed. .025 r > CUMULANT LETHALITY (esdoy)™! The integral may be evaluated numerically, using numerical data to specify X(t), or it may be evaluated analytically by first fitting Z(¢) with a graduation formula. In the event that the model is validated for application in a given range of conditions, and given also that an acceptable estimate of C, exists, then Equation 32 becomes a formula for estimating the expected relation of dose and survival time for a given time-pattern of exposure. il! Rucumulant to the daily X-ray cumulant the lethal injury. Inspection of Figure 4 will show also that this contribution in the first few days ig actually comparatively small. Fractionated exposure, like time-dependent exposures in general, have an important role in the development of the theory of lethality, but this contribution will come from considerations quite unrelated to the wasted radiation concept. interpretation. The linear model may have utility for prediction of the effects of timedependent exposure patterns, but its range of REFERENCES 1. Srorer, J. Rate of Repair of Radiation Damage in Mice. This velume pp. 3-100, 2. Motz, R. H. Quantitative observations on recovery from whole body irradiation in mice. I. Recovery after single large doses of radiation. British Journ. Radiol. 29, 563-569, 1956. TI. Recovery during and after daily irradiation. Tbid., 90, 40-46, 1957. a. Kress, J. 8. Ro. W. Braver, and H. Kaupace. Further investigations of the nature of nonrecoverable radiation injury. (Abstract) Radiation Research, &, 487 -488, 1956. 4, Vocer, H. B., J. W. Cuanx and D. L. Jorpan. Fractionation and protraction of Cogamma radiation-—-a study of acute lethality in mice. (Abstract) Radzatton Research, 6, 601, 1956. . Part, H. M. and A. M. Baves. The pathological physiology of radiation injury in the mammal. IL, Specific aspects of the physiology of radiation injury. 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