leg
in normal mice and mica
and
the mice
rad iucrements 24 hours apart.
after irradiation and
Animals
All itGu rad anisals dieu by
the survivors
had a very
the “iltn
cay
low CFU-S content oF about 2
receiving a 25. tua cose at 24 hour intervals tad an
equal depression of
their CFU-S,
isllowed by an exponentis
te
perc leg.
in tout 159
siugle douse or 1009 rad
it a
1C0u rad
receiving
ldv, VGO, or 30 ras
receiving a single Gose of
recovery
is
near normal levels by 3U days after exposure.
Geath in
the
irradiated animal
living primarily
in
in the LD, ranse.
the ygastroiutestinal
'
¢
ul
c
r
1
ib
a
u
5
ts
we
u“
Bacterial infection has long teen estauvl
ow
Therapy of Whole Body Radiation Injury
The commensal organiss
tract are
the tistal
orgzaisms
tt.
xill the animal that is irradiatec in the LDsq range (li, 26, 33-49).
The
use ot antibiotics as an effective treatment was first shown by tiiler et
al. (41)
with the administration of streptumycin in mice.
germ-free aninals have
teen studies (42, 43) ane
In acdite
these auniwals live lecger.
dying from hemorrhage anc anemia rather than infection in the absence
bacteria.
The effectiveness
lethal dose
level
since
of entibiotics faulis oft as one
to
marrow cegeneration ensues.
tne antibiotics being
Taketa (464) has
tne
1
rat.
ri
4
in
(228Se
Sluuie3s
microorganisms play a prominent riie
death in
the
rat,
and
iautensively stucied the
.t vas ciearly
in the genesis
this was mor:ified by
of acute
intestinal
inte
snmem tuert
Latsstine
It is a beneficial
ioc
ba.
effect not Limited to rodents. 7:3s have been treated with success
fluid replaceient,
traasfusion.
(47).
In the
letter study,
combined with successive antiblotics.
organisms of
bloua
in view of
Witn
«= ar-natic
improvement in mortality .as obtained by Coulter et al. (45),
and Allen et al.
osiss
the use of ancinistic: and
intensive administration of water and electrulytes.
antibiotics,
lv:
used belore tone
therapy against tre actuUie
of water-electrolytes and autidiotic
Geain
the
sone marcrcw regeneratisa is delayed =o9 ling tmet
bacteria develop resistance
radiation
nears
of
Hanmond
(45°,
trausrusions were
che
fact that conmeraal
the intestine are frequently culcuread from tne slooc of
tne
fatally trradfated mouse, webster (48) tested the effect of oral aeome rica
in
siunai
fror 769 rad
sooTe 4k
through 2500 rac.
rats.
Gracea
Neonvein
teant proiensation of the mein survical tio. oc:
be
treatment resulted
used
body x-irradiation of
a
sadiation were
from snole
»
coses of
the nortality
rh
therapy upon