te% and GO, is approximately 00 rac.
tor ranis
in
the vicinity of
,
irradiation nave
levels
of about 27
Prubable
the
severe
Fact
(26)
one would
rr
Fresh whole blooc ane 9
‘
the survivel rate.
(27)
therapeutic tctal
Urrects of
that antibiotics
et al.
This
rac.
cf
increase
therapy.
rematepuretic cepression occurring at cose
Cn clinical grounds,
antibiotics,
that patients given
the ebsence
incrgs:e
think that the combined use of
alten
een
o
dody
is bolsterea by
369 rad micline in
of any efrective
ow
estimate
Utraura,
can wake a first Suess
t
a
the Lie,
oe
et
uv
thas
Thus, one
trunsiZusions when neeteu, wouls
learly snrown by Miller ez al
the survival rate of
irraciated mice.
obtained no markec benefit from antibiotic and
trerapy in their stucies.
Furth
transfusion
nN
Cvtsequent
stuaies by Sorenson et al. (25) ane
Perman et al. (29) bave clearly shown that one can consistently reduce
rortality from a near
This enables
uncomplicated whole
one
to
clatelet-rich plasna when
“4
a
be
needed.
supplemented by
the
successive antictiotics anc whole bisod
No
transfusioms
high dosage of
Ua
combined use of
LOG fatal cose to about 1b mortality in dogs by
it
rad cells aze not
the sisnoidal dose mortality curve
of
Doay radiation injury to a much steeper one snittin
the LDsy from approximately 3U9 raq in the aog to a little over 40% rac.
The 5% mortality is shifted frum reuyaly 250 tac to about 460 rad rtesultin,
in
A
Tag
,
neariv
licrle
although
gucid
wae ei Aa
beneric
a toaeman tele
is
the survival
cvartality
curve.
Alter cuscs
ia
BASSso
UL
oe
observec unc Wita greater coses nu animals sutvive,
time is moderately increased.
Thus, one can
anticipate that antadiotics, Lrvvd transftusiuns ana platelet transfusions
would benefit muman
The
relatiouship
in dozgs ard man
ef
beings.
further points up
antibiotics,
were exposed
Pp
uf rortality
In Figure 2
to &
gamta
te
the
im the granulocyte count
impurtant role of
is shown
The granulocyte curve at
avout 607
infection anc value
the sranulocyte cvunt in dogs
radiation from a nuclear bemb and
with percent mortality.
that were exposed
to derressica
rad midline dose.
the correlation
the far
“Note
that
left is in doxs
that
the bl<od
counts Geclined and all animals were cead by the seventh day cf exzosute.
At autopsy
infection was clearly
the major cause of
death.
In
the next
Curve the mortality was also 1707, with a slower decline in granulocyte
longer survival tine.
“Jd
count along witn a
Sao tkwss
at autupsy the major cuuce of