answer of the Counittee = The anawer is substantially the same as to
Question isthat
3,
at least eight miseiens can be earried cut.
Personnel cought to be carefully checked and evaluated after each nission.
The possibility of substantial reduction in life expectanay by radiztion .
doses totaling ever 20Grshould not be ignored.
Biology Sranch (guuieGneeas
Human Genetics ~ At the November ncating of the Biology end Kedicine
Advisory Committee the question of supporting work in human genetics was
discussed.
In compliance with the general tenor of the discussion, a
propesal for investigation of certain humen mutation rates wag invited from
Dr. James ¥. Neel. ef the University of Michigan whe had discussed this problex
@m several previous occasions with Dr. Zelle. br. Neal's greposal will be
disacuased at the January aceting of the Advisery Comaittes andwill be the
firet research contract in human genetios if if is approved. This wrk sill
“pet
ee takeOM
woe
not deal with the effect of irradiation but enly with paturally ocouring
mutationg in man.
hengextty Studios - Some of the aioe surviving operation Greeshouse are
tc ba re
tad States for observations aver the rest of théir
life span.
‘This work will be done in the Siology Division at GRYL. The
Stology Branch ws represented by Dr. Zelle at the December 1th Gonference
at Oak Ridge to discuss specific plans for the cataract, tuner incidence, and
longevity studies of these mice.
The sverall sise ofthe study wes reduced,
a better statistical denign developed especially for the control mice, ands
convenient ayaten of recording data on tha ISM eard outlined at the ocufarmee.
Personnel requirements, finsncing, end other problems perteining to the program
were discussed,
the studies on the longevity of the aice fron dreonhouse oomprise only
one part of a program on the effects of radiation on longevity. Other studies
. using external seurses of radiation will be initiated with dogea and other
species, Aninals will be exposed to single »ray treatments at various dosage
levels, ad also to intermittent exposures,
Irradiation iffects on Plents ~ Hesearch at the U. 3. Department of
agriculture at Saiteville on mm ACC project has dealt extensively with the
effect of radicactive isotopes on plant growth. In messuring the immediate
effect of irradiation on plants it has been possible to measure a decrease
in root length, in top growth, and the sise of new leaves. These sethods are
only qualitative and with thea little visible injury to plants is noticeable
in such planta a# barley and alfalfa when the plants are grown in nutrient
solutions containing less than 50 microcuries of p22 per Liiexs
It bas recently besn observed that oall division ceascs in the meristematic
region such as the root tip or atem tip when subjected te s« constant relatively
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