RI > and cases ; : Cronkite Posed by etal. 1956 - > ANDRE EWS u Similarly revealed 100 90 ef < 3 8 theMinimal] a 70 critical 6 months| Go wo} a stage (weeks Pa 4-7) fof f ---Lyear _ = 50 wel a and reticulu Compari| n “7 Byears = 40 ase m cell A i of g2 60 es. 69 Hematological Effects on Heavily Irradiated Japanese Fistesmer ex E 30 | ivich Fig. 4 g with no rma; . - Leukocytes of Bikini (J) (cumulative). . ° 20 patients 0 - contral f f oe ; 12345 oo, 6 7 & § 10111213 leukocytes «103 x 103 — 1-3 2 ee .~ - = > _o.2. "a Me at eo Ld tet 7 . se. . 7 ony! J . - ta “nS “4 . nt. s * ~.* es fee? * s. ~ ‘ang A? ‘ wr =9 ££ o org Bot ! annaBit at Sth 3S oF 2 ar 5} Week al- Ormalities of 1 In Dorm ee al Pé€rsons a! re x, Xamin ed on an an- < nae fF ee vey O 7 1421283542058 70 days . 5 6 months aot . 123456 78 9 101) 12131415 time after exposure years of normal Japanese. In the case of erythrocytes, 2 years after the expusure, the curve approximately came back to normal. A similar tendency is seen in the cumulative distribution curves of platelets. However,in a few cases slight neutropenia is still observed. Figure 5 shows the changes of total leukocytes, neutrophils, and lymphocytes of 2 cases which are representative for severe injury. A small increase of “mitotically connected abnormalities”, i. e. karyomeres of erythroblasts, were observed in bone marrow smears of a few cases after 10 years. = Cytogenetical studies have been performed since several years. The results are summarized as follows (IsnmHarna and Kumatoni 1965; 1967; 1969). 1. The frequency of aneuploid cells was 2~3 per cent, which was not 3 © the left of the slightly to the left En ie - . . =. s & Fig. 5 Changes in the numberof leuko- cytes, neutrophils and lymphocytes. ry aa 70° 6M WY ay + qT lymphocytes - STanulations Tata ee totic abn Cre ed: nuclear debris of phils, toxic =~ NW mom oO “Oo 2 1|<103 70 12|11+ Served, Wi ‘Oplastie andiththe the begin. n tur ned