Procedures: Medical Histories and Physical examinations will be recorded on the special sheets (Enclosure IV) which will be furnished later. Available will be a copy of the previous years' exams and a brief summary of past medical findings. The examining doctors should review the medical history and, with the T.T. medics, expand on it if necessary. The summary of significant positive. findings should be completed on the last page of the exam forms. The examining physician should initial the routing sheet. The examining physician should personally confer with each subject, giving them briefly the results of the exams and proposed treatment. He should initial the checkoff list for this on the routing sheet. In addition to routine physical exams, more detailed or special exams of certain organ systems will be emphasized: Cancer Detection This is the most important aspect of the exams with particular emphasis placed on screening for possible malignancies that are recognized.as being associated with radiation exposure. Since cancer statistics are sparse for the Marshall Islands, documentation of these findings is of particular importance. Thyroid Examinations Routine inspection and palpation of the thyroid and neck with drawings of the thyroid are indicated. Note clinical evidence of thyroid function. A sheet with a thyroid drawing is attached to the physical exam forms. Plasma will be collected for TSH on designated Rongelap and Utirik people. As referred to above, additional thyroid exams will be carried out on unexposed Rongelap and Utirik people living at Majuro and Ebeye. Those with thyroid nodules will be evaluated for surgery and if needed referred to the U.S. for surgery. These control studies are needed to establish a better basis for the incidence of thyroid cancer in the Marshallese people. Leukemia In addition to hematological evaluation, careful exam of the lymphatic system including liver and spleen will be done. Lungs An x-ray machine will be available for routine chest plates. Such x-rays will be evaluated on all patients with abnormal findings on physical exam. Breasts Referral is possible for biopsy or possible surgery of any cases with suspic- ious findings in the breast. be done. Honolulu is the nearest place where mammography can . Stomach and GI Tract Rectal exam should be done on all subjects > 40 years of age with test of feces on glove for occult blood ("Hematest'). Flat plates of the abdomen may be done. Proctoscopic exam can be done if indicated. Genitourinary Pelvic exams on all mature females (greater than 14) with two Pap smears to be fixed (Cell-Guard for later staining and reading). If indicated biopsy of the cervix and uterine washings will be performed as indicated. Gram-stained smears for GC may be done. Serology for syphilis will be done on those not previously tested and repeats on certain people with positive titers to determine if the dis- ease is quiescent or progressive. In older people (greater than about 30) previous yaws infections may cause false positive syphilis reactions. (lab-stix) and microscopic if indicated will be done. IUSTabzZ Urine exam, routine (See Enclosure V).